Ksizal - antihistamine having the ability to prevent the development and facilitates the allergic reactions.
Antihistamines and antiallergic properties due Ksizal effect of levocetirizine, the active ingredient of the drug.
Levocetirizine has the ability to block histamine receptors, to reduce the migration of eosinophils (inflammatory cells), reduce vascular permeability, slow release of inflammatory mediators.
Ksizal, reviews confirm, has also antiexudative (prevents the fluid in the tissues, eliminates the increased vascular permeability) and antipruritic effect.
A significant calming effect Ksizal not. In most patients, the therapeutic effect of the drug is observed after 30-60 minutes after administration and persists for days.
Take Ksizal guide recommends that adults and children over 2 years. The drug is indicated for:
- allergic rhinitis, seasonal and perennial periodicity;
- allergic conjunctivitis;
- hay fever;
- allergic dermatoses which are accompanied by rash and itching.
According to the instructions, Ksizal not accept patients suffering from:
- individual intolerance to levocetirizine or piperazine derivatives;
- chronic renal failure severe.
Ksizal tablets are not indicated for children under 6 years, patients with lactase deficiency, galactosemia, malabsorption (inadequate absorption) of glucose-galactose.
In the absence of data on the impact of the drug on the intrauterine development of the fetus, for pregnant women Ksizal instruction is not recommended. The ability of levocetirizine passes into breast milk explains the ban on the drug during lactation.
Although Ksizal reviews describe as an effective anti-allergic drug, caution should be taken in patients of advanced age, persons suffering from chronic alcoholism and in patients with impaired renal function.
Instructions for use Ksizal
Ksizal produced in the form of tablets or droplets, which are intended for ingestion.
Ksizal tablets should be taken on an empty stomach or during meals, without chewing or crushing. The recommended dose for adults, patients with impaired liver function, elderly persons without disabilities in renal function and children older than 6 years - 1 tablet per day Ksizal.
Patients with impaired renal function dose adjustment is needed: Depending on the creatinine clearance is assigned to 1 tablet every 1-3 days.
Patients on hemodialysis Ksizal tablets are contraindicated.
Ksizal drops for adults and children over 6 years is prescribed once daily 20 drops, if necessary, recommend can be diluted with water (no more than 1 tablespoon). Children 2-6 years Ksizal drops should be taken two times a day 5 drops. Patients with kidney disease need a dose adjustment.
If hay fever take Ksizal guide recommends for 1-6 weeks, and chronic diseases, treatment may be extended up to 1, 5 years.
Ksizal reviews classified as good tolerability, as adverse effects have been extremely rare.
As a result of clinical trials, it was found that the tablets Ksizal drops and may cause:
- depression, headache, fatigue, drowsiness, loss of visual acuity, aggression, convulsions;
- dry mouth, discomfort, and epigastric pain, diarrhea, nausea, elevated liver enzymes, hepatitis;
- pruritus and rash, urticaria, angioedema, anaphylactic shock.
Ksizal be fit for use for 3 years if stored in a dry place at a temperature not exceeding 25