Biosulin - short-acting insulin.
Release form and composition Biosulin
Biosulin injection, a clear, colorless liquid. The main active ingredient Biosulin - genetically engineered insulin 100 IU per 1 ml of the drug. Auxiliary components: cresol, glycerol and water for injection.
Pharmacological action Biosulin
The drug has a hypoglycemic effect.
Biosulin - human insulin produced by recombinant DNA technology.
Due to exposure to a specific receptor outer cytoplasmic membrane, it forms a complex of insulin-receptor which stimulates intracellular processes such as glycogen, pyruvate dehydrogenase, hexokinase. It increases intracellular transport, thereby reducing the level of glucose in the blood. Reduces the rate of glucose production by the liver, enhances the absorption and assimilation of its fabrics.
Indications of the drug Biosulin
- Insulin-dependent diabetes mellitus (type 1);
- Non-insulin dependent diabetes mellitus (type 2), including the step of resistance to oral hypoglycemic or with partial resistance according to the means in intercurrent diseases as combination therapy;
- The condition of patients with diabetes mellitus requiring urgent intervention and accompanied by decompensation of carbohydrate metabolism.
Contraindications to receive Biosulin
- Increased idiosyncrasy of insulin or other components of the drug.
Application Biosulin during pregnancy and lactation
No reviews Biosulin regarding use during pregnancy and lactation is not.
Possible side effects
Reviews Biosulin patients revealed these side effects:
- Allergies: rarely skin rashes, angioedema. There were sporadic reviews Biosulin patients showing an anaphylactic shock.
- Local reactions: itching and swelling at the injection site, redness. With prolonged use at the injection site may cause lipodystrophy.
- Metabolism: possible hypoglycemic state (pale skin, sweating, hunger, tremor of the extremities, heart palpitations, headache, paresthesia in the mouth, restlessness). Strongly expressed hypoglycemia may lead to hypoglycemic coma.
- Other adverse reactions: the occurrence of edema. At the beginning of therapy may be transient refractive error.
Interaction Biosulin with other drugs
Reviews Biosulin and clinical studies revealed a number of drugs that affect the person's need for insulin.
Oral hypoglycemic drugs, ACE inhibitors, MAO, carbonic anhydrase, bromocriptine, sulfonamides, non-selective beta-blockers, tetracyclines, anabolic steroids, ketoconazole, clofibrate, mebendazole, cyclophosphamide, drugs lithium etanolsoderzhaschie drugs, fenfluramine, pyridoxine - all of these drugs can enhance the action of insulin .
Oral contraceptive drugs, thyroid hormones, corticosteroids, thiazide diuretics, morphine, diazoxide, nicotine, phenytoin, clonidine, danazol, tricyclics, heparin, sympathomimetics, BPC - these drugs impair the hypoglycemic effect of insulin.
Salicylates, and reserpine can both strengthen and weaken the effect of insulin Biosulin.
Dosing and dosing Biosulin
In / in, in / m, n / a half an hour before a meal containing carbohydrates.
The dosage of the drug your doctor prescribed individually on the basis of the content of glucose in the blood.
The average daily dose of 0, 5-1 IU per kg body weight.
Temperature of insulin must be room.
Monotherapy drug is taken three times a day (if necessary up to six times per day). When the daily dose is greater than 0, 6 IU per kg body weight, administered two injections of various body parts.
Insulin is most commonly administered Biosulin p / c in the abdominal area. Also injected into the thigh, shoulder muscles and buttocks. Periodically change the injection sites to avoid lipodystrophy.
The drug is administered only under medical supervision.