Calcium hydroxyapatite formula

Calcium hydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2   an inorganic basic component of bone tissue.

Produce Hydroxyapatite drug coral genus Porites, which is mined in the sea. Completely inert to human tissues due to this has been widely used in dentistry, traumatology, maxillofacial surgery. In cosmetology Hydroxyapatite is used to smooth out wrinkles.

Pharmacological group: control Calcium-phosphorus metabolism

Dosage form

Calcium hydroxyapatite is produced in the form of powder, suspension, granules and pastes.

Pharmacological action

By adjusting the exchange of calcium and phosphorus, the tool itself is the base matrix of bone tissue is inorganic nature. By activating bone formation, increased proliferation of osteoblasts and in the introduction of reparative osteogenesis process started, which inhibits inflammation in the bone wound. Once the cavity is filled with bone, calcium hydroxyapatite does not harden, and does not resolve, and it takes a full replacement of bone tissue.

Gidroksipatit calcium low toxicity, if its application is not observed side effects (inflammation, allergy, mutagenic effects).

Indications Hydroxyapatite

For stimulation of reparative osteogenesis in maxillofacial and plastic surgery, traumatology and dentistry Hydroxyapatite is used:

  • as the fulfillment of the missing elements of bone tissue;
  • periodontitis;
  • to restore bone defects after removal of seizures;
  • for wounds with damaged bone tissue (eg. gunshot);
  • in different types of fractures;
  • formed under false joints;
  • for the introduction of prostheses and implants;
  • when plastic facial bones.

For use as an ingredient in the dental filling filler pastes Hydroxyapatite used in:

  • pulpitis;
  • periodontitis;
  • Filling of bone defects - after removal of the cyst;
  • filling defects after resection (partial removal) apex;
  • deep caries;
  • to fill root canals.

Hydroxyapatite is also used in cosmetics for intradermal injections for wrinkles.


In case of individual hypersensitivity to the drug.

Side effects

Do not observed.

Instructions for use Hydroxyapatite

 Calcium Hydroxyapatite
 Hydroxyapatite calcium powder mixed with saline solution and etilglikolem either oily solution retinolatsetata to pasty consistency. The paste must be used within two minutes after its preparation.

Hydroxyapatite calcium granules are used to fill the pockets with periodontitis. For this pocket is prepared in advance, and then it is filled densely granules

Hydroxyapatite as a ready paste can be directly introduced into the injured part of the previously prepared bone (removing necrotic tissue or modified) or the place where you need to fill in the defect, followed by cross-linking of the soft tissue layer by layer.

5% suspension was injected into the cavity of bone defect with a syringe.

To restore the previous height mezhalveolyarnyh walls and fill the defect of alveolar process using 45% paste.

For the treatment of periodontitis using 18% hydroxyapatite paste.

10% suspension of hydroxyapatite used in the case of conservative treatment of periodontitis.

To smooth out wrinkles in cosmetology Hydroxyapatite administered by intradermal injection as a filler in the form of an aqueous solution.


Using the drug for bone regeneration, in the acute phase of inflammation of soft tissues accompanied by suppuration is considered inappropriate.

If necessary Hydroxyapatite can be sterilized in a hot air oven with an unlimited multiplicity of repetitions at temperatures up to 150 C, with an exposure of at least 10-15 minutes.

Storage conditions

Store in a dry place.