Human immunoglobulin
 Immunoglobulin - immune-stimulating drug.

Pharmacological action

Immunoglobulin - globular protein, which is produced by special cells of the human body and is involved in the formation of an immune response.

There are several types of protein: IgE, immunoglobulin g, Rh immunoglobulin, human. They differ in amino acid composition, function and structure.

Immunoglobulin E is found in small amounts in the secretions, blood, serum. Most often, the study carried out on its content to identify atopic allergic diseases. The rate of immunoglobulin (in Re / l): 1-3mes. - 0-2;

3-6mes.- 3-10; one year - 8-20; 5l. - 10-50, 15L. - 16-60; adults - 20-100.

Immunoglobulin g responsible for antibacterial protection. If the rate of immunoglobulin is exceeded, then the human immune system is already struggling with pathological antigens, so the data analysis allowed to detect the disease, start treatment.

The human immunoglobulin contains a large number of antibodies against a variety of pathogens. Through it decreases the chance of infection infections in immunocompromised patients, lack of g-filled antibodies.

Rh immune globulin is administered for the prevention of Rh sensitization, it destroys the red blood cells of fetal Rh-positive in maternal circulation, preventing the production of antibodies protivorezusnyh mother.

Product form

Immunoglobulin produced in the form of a solution for intramuscular injections, and intravenous administration, powders for their preparation.

Indications immunoglobulin

IgE is prescribed for allergic diseases: pollen allergy, atopic dermatitis, food and drug allergies, eczema, bronchial asthma, with helminths. IgE also used to evaluate the development of allergies in children.

Immunoglobulin g effective in infectious diseases, liver cirrhosis, chronic autoimmune, viral hepatitis, systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis, multiple myeloma disease, AIDS, cancer pathology, HIV infections, sinusitis, sepsis, meningitis, pneumonia, otitis media, as well as for monitoring replacement therapy immunodeficiency.

Immunoglobulin is prescribed for human congenital hypogammaglobulinemia, agammaglobulinemia, subclass deficiency Immunoglobulin g, severe combined immunodeficiency, for replacement therapy in chronic lymphocytic leukemia, myeloma, AIDS in children. Human immunoglobulin is also used to suppress inflammation, immunomodulation at Kawasaki syndrome, bone marrow transplantation, immune thrombocytopenic purpura origin.

Immunoglobulin is prescribed to women with Rh negative Rh, which are not developed Rh antibodies.

Also, this type of immunoglobulin used in cases of abortion in women with Rh negative.

 mode of application

Immunoglobulin is administered intramuscularly, intravenously. The scheme of administration are determined individually in each case.

The appointment makes physician on the basis of a deviation from the norm of immunoglobulins.

side effects

Side effects after the application of immunoglobulin E, immunoglobulin g, human and Rh immunoglobulin, are rare, disappearing shortly after the end of treatment.

After immunoglobulin may appear shortness of breath, dry cough, diarrhea, stomach pain, nausea, tachycardia, vomiting, cyanosis, flushing, pain in the sternum, weakness, drowsiness, symptoms of aseptic meningitis, deterioration in renal failure, renal tubular necrosis, allergic reactions. excessive salivation, back pain, myalgia, hiccups, aches in the joints, sweating.

Contraindications to the use of immunoglobulin

Immunoglobulin can not be used when renal insufficiency, diabetes mellitus, acute phase of allergies, anaphylactic shock (as a reaction to blood products).

Caution should be exercised by appointing the drug during lactation, pregnancy, migraines, chronic decompensated heart failure, a disease which was caused by immunopathological mechanisms.