Grippostad - combined agent having antihistamine, antipyretic and analgesic effect.
Release form and composition
It is produced in the form of powder for oral solution in 5 g batches, in carton 5 or 10 packages.
In one bag of the drug contains the active ingredient - acetaminophen 600 mg and auxiliary ingredients: sucrose and ascorbic acid.
Paracetamol refers to a group of non-steroidal anti-inflammatory agents. It inhibits the activity of the enzyme cyclooxygenase, thereby slowing the production of prostaglandins, prostacyclin and thromboxane from arachidonic acid.
Preparation Grippostad acts predominantly on the nerve tissue due to inactivation of paracetamol cellular peroxidases, missing in the nerve cells.
Analgesic properties of paracetamol is due to inhibition of nerve impulse generation and the nerve structures. Due to the direct effect of the drug on the thermoregulatory center located in the hypothalamus, there antipyretic effect.
Grippostad according to the instructions indicated for the symptomatic treatment of patients with increased body temperature, including acute respiratory disease.
Also Grippostad of instructions can be used for relief of pain of moderate severity in patients with toothache, headache and algomenorrhea.
The drug is administered orally. Immediately before use, the contents of one packet is dissolved in a glass of hot boiled water. Drink ready to drink immediately after cooking. To reduce the risk of side effects from the digestive system, it is better to use a drink after a meal.
Dosages and duration of treatment is determined individually by the attending physician.
As a rule, the dosage instructions Grippostad for teens and adults whose body weight more than 50 kg, is one bag up to four times a day.
Teenagers and adults weighing less than 50 kg should receive one packet three times a day.
The maximum single dose Grippostad instructions for - 15 mg per kg body weight. The maximum daily dose - 60 mg per kg body weight.
It is undesirable to take a day more than four packets of the drug. The interval between doses should not be less than 6-8 hours.
The duration of treatment is five days.
Reviews Grippostad patients show its good tolerability. In some cases reported of adverse effects caused by the actions of paracetamol, in particular:
- The cardiovascular system and the hematopoietic system. It may develop hypotension, flushing of the skin of the upper body and face, leukopenia, thrombocytopenia, pancytopenia, agranulocytosis.
- Hepatobiliary system and the gastrointestinal tract. The event of nausea, vomiting, elevated liver enzymes, pain and epigastric discomfort.
- Allergies. Perhaps the development of eczema, urticaria, pruritus, angioedema, bronchoconstriction, anaphylaxis.
In the case of abrupt withdrawal of reception Grippostad after prolonged treatment may develop anxiety, myalgia, headache, fatigue. Within a few days these symptoms should pass.
Grippostad of instruction is contraindicated in:
- congenital deficiency of glucose-6-phosphate dehydrogenase;
- severe hepatic impairment;
- The deficiency of aldolase with glucose-galactose malabsorption;
- hypersensitivity to disaccharides;
- hypersensitivity to paracetamol or auxiliary components of the drug;
- children under ten years.
Reviews Grippostad patients showed that it should be given with caution to persons with reduced renal function, hyperbilirubinemia, chronic alcoholism.
Application Grippostad during pregnancy and lactation
Your doctor may prescribe Grippostad receiving instructions on pregnant women in the case, when use of the drug exceeds the damage to the unborn child. It is not allowed during pregnancy prolonged treatment with paracetamol.
During breastfeeding possible single dose of paracetamol. After receiving breast-feeding is not recommended for three or four hours.
Interaction with drugs Grippostad
Combination drug carbamazepine, phenobarbital and phenytoin rimfapitsinom and with ethyl alcohol, may cause a substantial increase gepatoksicheskogo action of paracetamol.
Simultaneous treatment with paracetamol with chloramphenicol increases its toxicity and slow elimination from the body.
Reviews Grippostad indicate that caution should be taking it in combination with oral anticoagulants.
Preparation Grippostad, reviews many patients in combination with AZT, it enhances the development of neutropenia, and in combination with metolklopramidom increases intestinal absorption of paracetamol.
Reviews Grippostad patients show that excess dosage can cause vomiting, nausea, violation of wakefulness and sleep, headaches, excessive sweating, pain and weakness in the stomach, fatigue.
With a strong overdose develops intoxication, accompanied by hepatic impairment. For complex poisoning may develop hepatic coma.