Furagin - synthetic antimicrobial agent.
Furagin belongs to the group
nitrofuran antimicrobial agents. The active ingredient of the drug - furazidin. Its mechanism of action is based on inhibition of the formation of nucleic acids in bacteria, making it impossible for their reproduction. It destroyed the outer shell of the bacteria and their cytoplasmic membrane.
In addition, the microorganisms are suppressed most important biochemical cycles (including - the respiratory chain and the citric acid cycle), and it violates their vital functions, causing the bacteria begin to generate less waste products and toxins. This leads to an improvement in the condition of patients before the death of pathogens.
The main effect of furagin instructions - bacteriostatic, bactericidal concentrations achievement possible with a dosage of 2 times bacteriostatic. That means bactericidal concentrations are achieved in the urine during injection of the drug from the body.
Furagin active against gram (staphylococci, streptococci) and Gram-negative bacteria (E. coli, Salmonella, Shigella, Klebsiella). Application furagin ineffective in cases where infectious agents are Pseudomonas aeruginosa, enterococci, Proteus, serratsii and some other microorganisms.
This medication is able to activate the immune system. Furagin increases blood levels of non-specific protective proteins (complement) and enhances the ability of white blood cells to destroy harmful bacteria. These distinctive ability to determine the benefit of using furagin over other antimicrobial agents.
Furagin by manual release tablets and capsules of 50 mg, and in the form of soluble powder in 100 g cans
The drug is used in treatment of urinary tract infections, acute and chronic recurrent (cystitis, pyelonephritis, urethritis, infections of the female genital organs). It is suitable for children and for long-term bladder catheterization in adults.
In the opinion of Furagin as a solution for outdoor applications effective in the treatment of keratitis, conjunctivitis, burns, wounds festering for washing. As a means to prevent infections it is used for diagnostics (cystoscopy) and operational manipulation in urology, for washing the cavities with the pleural empyema, peritonitis.
The drug acts only on microorganisms which are sensitive to it.
Despite the indications for furagin if increased sensitivity to it, and if the patient has concomitant severe renal impairment, the tool can not be used. Do not use it in children under 1 year old, pregnant and lactating women.
Caution is required to use the drug in the liver, the nervous system, as well as local use in children under 1 month.
Instructions for use furagin
Tablets and capsules taken after meals, drinking plenty of water. Adults designate an average of 50-100 mg three times daily, a course of 7-14 days after the break requires 10-15 days. If necessary, after the break, the course can be repeated.
Babies furagin dose should be calculated on the weight of the body - 5-7 mg / kg / day in 3 divided doses, duration of the course is the same.
0 aqueous, 5% or 1% solution for topical application, 0, 5 g or 1 g, respectively, were dissolved in 100 ml of hot water for injection. Then, the resulting solution should be filtered through a special anti-bacterial filter, pour into glass bottles and sterilize. This solution was used in ophthalmology diluted 1: 13,000 (in the eye instilled with 2 drops of 4-6 hours), and washing the cavities.
At home, for the topical treatment of septic wounds, burns can be prepared 1% solution furagin at 0, 9% solution of NaCl.
Side effects furagin
In the opinion of Furagin can cause allergic reactions, nausea, dizziness, vomiting, headache, neuritis and polyneuritis, violations of the liver.
To prevent possible side effects during treatment furagin need to drink plenty of fluids, take extra B vitamins and antihistamines.