Ftorafur - antimetabolite antineoplastic drug.
Structure and Composition Ftorafur
The drug release
in the form of hard gelatin capsules, orange and yellow cap body. One capsule contains active ingredient - tegafur 400 mg.
Additional components: stearic acid.
Cover structure: titanium dioxide, Ponceau 4R, gelatin, Quinoline yellow.
The plastic jars of 100 capsules.
According to the instructions Ftorafur is an antineoplastic drug that violates the synthesis of RNA and DNA. Hydrolysis formed fluorouracil, which inhibits DNA synthesis and enzyme thymidylate instead uracil RNA introduced into the structure to form a defect, inhibits cell proliferation.
In tumor cells, tegafur is converted to 5-fluoro-deoxyuridine-5-monophosphate, which is then phosphorylated to the triphosphate and incorporated into the structure of RNA and also floxuridine monophosphate, that inhibits thymidylate synthase.
In the opinion of Ftorafur not toxic, as 5-fluorouracil and much better tolerated by patients.
According to the instructions shown Ftorafur cancer rectum and colon, breast and stomach. Also, use in patients with cutaneous lymphomas and atopic dermatitis.
Dosing and dosing regimen Ftorafur
According to the instructions Ftorafur intended for ingestion.
The daily dosage of 20-30 mg per kg body weight, divided into two to four stages, but no more than two grams per day. The exchange rate of the dosage is 30-40 interval between courses of one month. In elderly patients, and also in the late stages of the disease may be reduced dosage formulation.
Ftorafur is contraindicated in:
- severe renal impairment, and liver;
- terminally ill;
- pregnancy and breastfeeding;
- acute profuse bleeding;
- hypersensitivity to tegafur.
In the opinion of Ftorafur be used with caution in patients with impaired kidney and liver, blood, glucose metabolism, as well as ulcer 12 duodenal ulcer and gastric infections and patients with a tendency to bleed.
Side effects Ftorafur
Ftorafur on responses may cause the following side effects:
- The senses: lacrimation, anosmia, diplopia, fibrosis of the lacrimal ducts.
- CNS: confusion, euphoria, dizziness, symptoms leykoentsefalita, ataxia, drowsiness.
- Digestive system: vomiting,
abdominal pain, nausea, anorexia, diarrhea, esophagitis, stomatitis, gastrointestinal bleeding, ulcerative lesions of the gastrointestinal mucosa, acute hepatitis, liver dysfunction, acute pancreatitis.
- The system of blood: anemia, thrombocytopenia, leukopenia.
- Cardiovascular: angina pectoris, myocardial infarction, false angina, myocardial ischemia.
- Dermatological reactions: violation of the regeneration of the skin and nails, alopecia.
- Other side effects: dehydration, impaired renal function, and allergic reactions (up to anaphylactic shock), pharyngitis, interstitial pneumonia.
Overdose Ftorafur Review leads to the following symptoms: depression of hematopoiesis and increased side effects of the central nervous system and gastrointestinal tract.
In the event of overdose it is necessary for a month to monitor the function of blood, if necessary, carry out the symptomatic treatment.
Application Ftorafur during pregnancy and breastfeeding
Ftorafur contraindicated in pregnancy and breastfeeding. Note that tegafur suppress reproductive function.
In combination with phenytoin Ftorafur is intensified action of the latter.
Toxicity increases when it is combined with inhibitors of microsomal oxidation.
The drug prescription. Store it at room temperature for no longer than four years.