Fraksiparin (international name - Nadroparin calcium) refers to a group of direct anticoagulants that have
antithrombotic effect. The drug improves blood circulation and normalizes cholesterol.
Widespread use Fraksiparin received as an effective drug for the treatment of thromboembolism and its complications.
Structure and Composition Fraksiparina
The main active ingredient - calcium nadroparin 5700-9500 IU.
Supporting components: calcium hydroxide, hydrochloric acid, purified water.
Fraksiparin available as a solution for subcutaneous injection in 1 ml ampoules.
Fraksiparin is based on a low molecular weight heparin, created in the depolymerization process. The drug enhances the action of antithrombin and accelerates the process of transition of prothrombin to thrombin.
Good reviews Fraksiparin has as a drug with a rapid and prolonged therapeutic effect. The drug normalizes the content of lipoproteins in the blood, anti-inflammatory and immunosuppressive effect.
After the introduction of the solution Fraksiparina for 3-4 hours up to 100% absorption. In the liver inactive metabolites formed several steps. Excreted drug is eliminated via the kidneys in the urine.
Before the start of treatment should be to diagnose the functioning of the liver and kidneys, to check cholesterol levels and blood clotting. For elderly patients (70 years), the drug must be administered in the minimum dosage.
Fraksiparin prescribed for the treatment of bleeding disorders, thromboembolic events, angina, myocardial infarction, circulatory disorders.
Positive feedback received Fraksiparin as an effective drug for the prevention of thromboembolic complications (respiratory distress, infection, heart failure) after surgery (general and orthopedic surgery).
Contraindication to Fraksiparina are hypersensitivity and intolerance of components, internal bleeding, pericardial effusion, pregnancy and breastfeeding, vasculitis, hypertension, coma, nervous system diseases, peptic ulcer, post-lumbar puncture, serious diseases of the digestive system.
With care prescribe a drug in hepatic and renal failure, diabetes and old age.
Instructions for use Fraksiparina
According to the instructions Fraksiparin administered into the subcutaneous tissue of the abdomen and maintain a fold of skin over the entire period of administration solution. The drug is administered to the patient in the prone position, holding the needle at right angles.
the drug is administered at 0, 3-0, 5 ml of 1 times per day. Before surgery administered 0 4 ml of solution.
The treatment course is 10-14 days, during which two times a day are administered 0, 5 ml Fraksiparina.
In accordance with the instruction Fraksiparina dosage during orthopedic surgery depends on the body weight of the patient:
- 40-55 kg - 0, 5 ml of 1 day;
- 60-70 kg - 0, 6 ml of 1 day;
- 70-80 kg - 0 7 ml, 2 times a day;
- 85-100 kg - 0 8 mL, 2 times a day.
After completing the course of treatment Fraksiparinom (on the recommendation of the attending physician) can be assigned to prophylactic therapy with oral anticoagulants.
Fraksiparin can cause internal bleeding and hemorrhage, dysfunction of the adrenal glands, thrombocytopenia, anaphylactic reactions.
In the long course of treatment may appear allergic reactions - skin rash, hives, asthma, skin necrosis, fever.