Fragmin (international name - dalteparin sodium) belongs to the group of direct anticoagulants that have  Packing Fragmin
 fibrinolytic and immunosuppressive effect. The preparation possesses anticoagulant effect and for treatment of cardiovascular diseases.

Structure and Composition

The main active ingredient - dalteparin sodium 25-50 mg.

Auxiliary components: sodium chloride, hydrochloric acid, sodium hydroxide, purified water.

Fragmin is available as a solution for intravenous injection in 1 ml ampoules placed in a carton of 10 pieces.

Pharmacological Effects Fragmin

Fragmin active influence on blood clotting. The preparation is based on a low molecular weight heparin with the addition of the concentrate particles mucosa of porcine small intestine, and as an additional purification was applied to ion chromatography.

According to the instructions Fragmin therapeutic effect is achieved within 3-4 hours after ingestion. The bioavailability is about 90%. Fragmin eliminated from the body by the kidneys in urine.

The course of treatment be prescribed with care to patients with severe diseases of the digestive tract, liver and kidney failure, as Fragmin increases the risk of internal bleeding. Also, the drug increases the risk of spinal hematoma when taken with other anticoagulants and preparations containing heparin.

In patients with thromboembolism in high doses Fragmin may occur sharp decline in blood pressure and cause a state of shock.


Fragmin is appointed for the prevention of blood clotting and thrombus formation during surgical procedures.

The drug is effective in the complex therapy for the treatment of venous thrombosis, angina pectoris, myocardial infarction and thromboembolism.

Instructions for use Fragmin

According to the instructions Fragmin be administered 200 IU 1-2 times a day or 100 IU 2-3 times per day. In an outpatient setting, as in a hospital, the exact dosage of the drug is determined by the attending physician at the patient's indications.

In the period of treatment is necessary to carry out regular monitoring of blood clotting. For patients with severe impairment of blood flow is assigned pre-coagulant therapy is indirect, and then added to the combination therapy Fragmin.

Patients with elevated  Solution for injection Fragmin
 risk of internal bleeding assigned 5-10 IU Fragmin solution intravenously 1 times a day. The drug is introduced gradually over several minutes.

One day prior to surgery Fragmin administered 5000 IU 1 times and at the same dosage for 5 days after surgery.

Fragmin solution after orthopedic surgery must be entered within 3-4 weeks of 5000 IU 1 time per day.


Fragmin is contraindicated in hypersensitivity and hypersensitive to the components of the drug, immune thrombocytopenia, internal bleeding, severe diseases of the digestive tract, endocarditis, diseases of the central nervous system, impaired vision and hearing.

It should appoint Fragmin during pregnancy and lactation. The drug increases the risk of abnormal development of the fetus, and during lactation have a negative impact on the mother's milk.

In rare cases, Fragmin during pregnancy may be appointed by the attending physician, if the effectiveness of treatment outweighs the risk of adverse reactions.

With care prescribe a drug in renal and liver failure, disruption of the functioning of the brain and in the elderly.

Side effects Fragmin

Fragmin may cause internal bleeding, thrombocytopenia, spinal hematoma, anaphylactic reactions, skin necrosis.

Chronic administration of the drug can occur allergic reaction - hives, itching, skin rash, angioedema, dermatitis.