Fluorouracil - anticancer drug. A representative group of anti-metabolites.
from the group of antimetabolites which reduces the rate of chemical reactions necessary for tumor cell division by blocking the formation of DNA, and in particular decrease in activity of the enzyme thymidylate synthetase and to the formation of RNA interference fluorouracil in its structure.
Fluorouracil is available in the form of a solution for intravascular and intraluminal introduction.
According to the instructions Fluorouracil should be taken in the event of the patient's colon cancer or rectal cancer, cancer of the esophagus, stomach, primary liver cancer, ovarian cancer, cervical cancer, bladder cancer, a variety of malignant tumors located in the head and neck, prostate cancer, adrenal cancer, penile cancer or carcinoid.
Instructions fluorouracil: how to use
The method of administration, dose and mode of application of fluorouracil in each case is determined by the patient himself. All this is determined depending on the state of health of the patient, the stage and severity of the disease, the condition of the hematopoietic system, and a plan of chemotherapy.
Fluorouracil is usually injected into the body intravenously or infusion, intra-arterial and intracavitary. There are several standard treatment drug Fluorouracil:
- 0, 5 g / m2, or 12-14 mg / kg daily for 3 - 5 days, a pause between courses 1 month.
- 0, 6 g / m2 one-time per week, the duration of the course 6 - 10 weeks.
- 0 6 g / m2 in the 1st and 8th days with other anticancer drugs, alternated with administration intravenously for 4 - 5 days.
Side effects of fluorouracil
According to the instructions Fluorouracil
It has many potential side effects. According to the reviews of fluorouracil most common side effects are nausea and diarrhea, anemia and leukopenia less. It is also possible violations of the blood coagulation system, cardiovascular system, reproductive system, central nervous system.
Fluorouracil may cause adverse dermatological (alopecia, dermatitis) and allergic (urticaria, bronchospasm) reactions.
Fluorouracil is contraindicated in case of pregnancy and lactation. It is also contraindicated in finding patient exacerbation of duodenal ulcer or gastric bleeding of any kind and the possible occurrence, severe anemia or leukopenia, thrombocytopenia.
Fluorouracil should be taken with extreme caution to patients who have been in violation of the liver and kidneys.