Fenilin - means interfering with blood clotting.
Fenilinvhodit the group of indirect
Mechanism of action it refers to vitamin K antagonists competing with vitamin K, Fenilin blocks the enzyme K-vitaminreduktazu. Because of this impaired hepatic synthesis of coagulation factors - VII, IX, X and prothrombin. Deficiency of coagulation factor interferes with the thrombus formation, lowers blood levels of lipids, making the vessels more permeable.
To start working in the body, Fenilin must accumulate to a certain concentration, because its effect is not immediately - begin 8-10 hours, and the maximum effect is achieved through 24-30 hours.
Control fenilina anticoagulant action based on the determination of the prothrombin time coagulogram - PV, normally it is 11-14 seconds. For the prevention of venous thrombosis sufficiently increase MF 2 times, blood in 3-4 times in comparison with the norm.
Fenilin rapidly and well absorbed from the digestive tract. Turning it occurs in the liver. Excreted by the kidneys as metabolites.
The drug is available in tablets of 30 mg.
According to the instructions of the drug is used in conditions where necessary prolonged decline in blood clotting. It is used to prevent and treat thrombosis, thrombophlebitis and thromboembolic complications (pulmonary embolism, and others.) And thrombosis in the postoperative period. Constant reception fenilina required if a person has mechanical prosthetic heart valves. The drug is used in the complex therapy with anticoagulant heparin.
Take the drug should be under the control of blood clotting. If the level of prothrombin below 70% of normal, high risk of bleeding. Do not appoint Fenilin blood diseases associated with coagulation disorders (hemophilia, hemorrhagic diathesis), in severe renal insufficiency, 1 trimester of pregnancy and if you are hypersensitive. The caution is recommended to use this tool in old age, cancer, problems with the kidneys and liver, ulcers and erosions in the digestive tract, anemia and gynecological diseases in the early postpartum period, during lactation. 2 days before menstruation drug you want to cancel.
Instructions for use fenilina
According to the instructions the dose selected for the duration of the testimony of the prothrombin time, maintaining the prothrombin index at the level of 40-60%. On the first day loading dose of 120-180 mg orally in 3-4 hours, and secondly - 90-150 mg / day, then - under the control of the VWP by 30-60 mg / day. The maximum daily dose of 200 mg fenilina.
While receiving the drug should regularly monitor coagulation, thromboelastogram, level of platelets in the blood and urine for possible hematuria.
the drug should be gradual. Sometimes patients palms painted in yellow and pink urine. In overdose fenilina it is a vitamin K antagonist, in severe cases, it is administered parenterally.
Side effects fenilina
Fenilin on responses can cause nausea, diarrhea, headaches, fever, allergic reactions, toxic hepatitis, disorders of hematopoiesis.
Long reception sometimes provokes hemorrhagic syndrome in the form of nasal, uterine, kidney, gastrointestinal bleeding, bleeding in internal organs or muscles.