Famotidine refers to the group of antagonists of histamine H2 receptor and for treatment of reflux esophagitis and peptic ulcer.
Famotidine inhibits the release (secretion) of hydrochloric acid. In addition, this drug reduces the activity of protein-splitting enzyme - pepsin. In the opinion of famotidine is beginning to have a therapeutic effect after only 45 -60 minutes after receiving the initial dose. The duration of action of the drug is determined by the highest dose, ranging from 12 hours to the day.
- Reflux esophagitis - inflammation of the lining of the esophagus caused by the ingress of acidic gastric contents;
- Zollinger-Ellison syndrome - a pathological condition in which there is a combination of a stomach ulcer and benign tumors of the pancreas;
- Peptic ulcer and duodenal ulcer.
Famotidine is an indication for the prevention and the development of peptic ulcer disease in patients who for a long time the therapy of systemic diseases with non-steroidal anti-inflammatory drugs (NSAIDs) or corticosteroids.
Use of famotidine
Dosage is chosen by the doctor individually. At an exacerbation of peptic ulcer disease it is usually administered once a day for 0 04 In some cases, it justified the use of famotidine twice a day for 0, '02 The duration of treatment should be from 4 to 8 weeks. After ulcerative defect healed gradually stop receiving famotidine. To prevent future exacerbations take medication at bedtime dose of 0, '02
With Zollinger-Ellison syndrome and reflux oesophagitis famotidine appointed four times a day for 0, '02
According to the instructions of famotidine may be used for the treatment of patients with impaired renal function. In this case, the daily dose should be reduced in accordance with the values of creatinine clearance.
In the opinion of famotidine is effective and increased secretion of hydrochloric acid. In this case, it is administered once daily, preferably at bedtime dose of 0, 02 - 0, '04
According to the instructions of famotidine can lead to the following side effects:
- Increased liver enzymes (transaminases);
- Cholestatic jaundice;
- Dizziness and / or headache;
- Violations of taste perception;
- Decreased appetite;
- Noise in ears;
- Mental Disorders;
- Arthralgia and myalgia;
- Increased body temperature;
- Skin rash;
- Violations of peripheral blood (leukopenia, thrombocytopenia or agranulocytosis). In the opinion of famotidine in very rare cases may lead to pancytopenia - a sharp decrease of blood cells;
- Alopecia baldness.
Use of famotidine is contraindicated in pregnancy and lactation, and in the presence of the patient are hypersensitive to the drug.
According to the instructions for use of the drug famotidine may be in combination with non-absorbable antacids (drugs that lower the acidity of gastric juice). However, it is necessary that between the administration of these drugs was the interval of at least two hours.
Form release famotidine
Famotidine is produced in the form of tablets, containing in its composition 0 02 g of active substance in a package of 20 pieces. The drug is also produced in large volume - on 0 04 In this case, in the same package - 10 tablets.
Analogs of famotidine
The drug famotidine has many counterparts: Famotsid, Famosan, Famonit, Famodin, Famogard, Ultseran, ulfamid, Toptsid, Pepsidin, Nevofarm, Letsedil, Kvamatel, gastrosidin, Gastrogen, Blokatsid, ACIP, Antodin and others.
Despite the fact that the pharmacies have a wide range of analogues of famotidine, it is desirable to apply the formulation assigned to you by the attending physician.
Famotidine belongs to the B-list and is not intended for the treatment without a doctor's prescription. The drug is stored in a dry, dark place, away from children.