Estriol (international name - Ovestin)
It refers to a group of hormones that normalize hormones, reduce inflammation of the genital mucosa and eliminate the symptoms of menopause. The drug helps to restore the vaginal epithelium and normalizes its microflora.
Structure and Composition
The main active ingredient - 0 estriol 5 mg.
Supporting components: dimethyl sulfoxide, suppotsir.
Estriol is produced in the form of vaginal suppositories for 0, 5 mg, vaginal ointments in tubes of 15 g and 2 mg tablets, placed in a carton 30 pieces.
The pharmacological properties of estriol
Estriol normalizes the vagina, removes the effects of atrophic changes during menopause in women and increases the protective function of the vaginal epithelium to infection and inflammation. The drug has a regenerating, anti-inflammatory and antimicrobial action.
Main components of estriol normalize blood cholesterol, improve microcirculation and increase plasma volume.
Estriol is completely absorbed, reaching maximum plasma concentration within 2 hours. The drug is excreted from the body by the kidneys in urine. The therapeutic effect lasts for 15-18 hours.
Do not take estriol during pregnancy because it can be a serious risk to the conservation and proper development of the fetus.
Estriol is indicated for use in the atrophic processes of the mucous membranes of the genitourinary system, severe menopausal symptoms in women (itching, burning, inflammation, hot flushes, fever, etc.), during rehabilitation after surgery on the genitals, infertility, urinary disorders, dyspareunia , urinary incontinence.
Instructions for use of estriol
According to the instructions candles estriol must be inserted into the vagina in the atrophic processes and inflammation. The course of treatment lasts 3-4 weeks. The exact therapeutic dosage of the drug and maintenance is determined by the attending physician at the patient's indications. Candles Estriol is administered gradually to 0, 5 g, 2 times a day.
Estriol in tablets taking 4-8 mg 1 time per day for 1 month. Repeated treatment appointed the doctor after an interval of 3-4 weeks. Dosage is gradually reduced to 0 to 25 mg per day.
Ointment estriol must be administered into the vagina 2-3 times daily for 0, 5 mg over 3 weeks, followed by 0, 1 to 25 mg once a day for 2 weeks.
During treatment, estriol should regularly undergo medical examination with a complete list of diagnostic tests (blood tests, ECG, immunodiagnostics, etc.).
appointment of estriol are hypersensitivity and intolerance to the components of the drug, thrombosis, thrombocytopenia, kidney and liver failure, internal bleeding, malignancy, hypertension, epilepsy, heart failure.
Estriol is strictly contraindicated during pregnancy and breastfeeding, as well as under the age of 18 years.
With care prescribe a drug for migraine, severe diseases of the digestive tract, mastitis, purple and circulatory disorders.
Side effects of estriol
Estriol can cause vomiting, nausea, dizziness and headache, pigmentation, inflammation of the mammary glands and their pain, muscle cramps, hypertension, blurred vision.
In the long course of treatment may appear allergic reactions - itching, burning, dry skin, urticaria, angioedema, bronchospasm, skin rash.