Erythromycin - macrolide antibiotics, synthesized strains of bacteria Strertomyces erythreus.
Ilozon, Ermitsed, Gryunamitsin syrup Meromitsin, Eriflyuid, Eritromen, Eritran - substitute drugs (analogs) Erythromycin.
Structure and Composition
According to the instructions Erythromycin available as tablets (100, 250 and 500 mg); in the form of an eye ointment; as an ointment for local and external application; as a lyophilisate for solution for intravenous injection. The substance of erythromycin - the main active component of the drug.
Pharmacological action Erythromycin
Erythromycin Erythromycin analogues and disrupt the formation of bonds between the amino acid molecules, blocking protein synthesis bacteria (no effect on the formation of nucleic acids). Erythromycin in high doses contributes to the manifestation of its bactericidal effect.
According to the instructions, or treatment with erythromycin analogues Erythromycin is indicated for diseases caused by Gram-negative (Haemophilus influenzae, Neisseria gonorrhoeae, Brucella spp., Bordetella pertussis, Legionella spp) or Gram-positive bacteria (Streptococcus spp., Staphylococcus spp., Synthesizing and not synthesizing penicillinase, alpha- hemolytic streptococcus of group Viridansa, Corynebacterium minutissimum, Corynebacterium diphtheriae, Bacillus anthracis), and Listeria monocytogenes, Treponema spp., Chlamydia spp., Entamoeba histolytica, Rickettsia spp.
Erythromycin resistant to Gram-negative rods Pseudomonas aeruginosa, Escherichia coli, and Salmonella spp., Shigella spp ..
Erythromycin sensitivity considered microorganisms whose growth is retarded by drug concentration of less than 0.005 g / L, sensitive to moderate - from 0 001 to 0 006 g / l, moderately firm and stable - from 0 006 to 0 008 g / l.
In the body Erythromycin is unevenly distributed. Most of it accumulates in the kidney, spleen and liver. Drug penetrates well into the synovial fluid and ascites, pleural cavity into lung tissue, semen. Concentration in CSF is 10% of the content of the antibiotic in plasma.
The main part of the liver is metabolized Erythromycin (about 90%). From 20-30% of bile output antibiotic buds - 2-5% Erythromycin unchanged (half-life - 1, 5-2 hours).
According to the instructions of erythromycin treatment is indicated in various infectious and inflammatory conditions, including respiratory infections, diphtheria, prostatitis, scarlet fever, amoebic dysentery, listeriosis, syphilis, cholecystitis, gonorrhea. Erythromycin is used to treat infections of the skin and soft tissue - trophic ulcers, burns, second and third degree, boils, infected wounds, pustular skin diseases. Furthermore, the antibiotic used for a variety of infections of the mucous membranes of the eyes (including conjunctivitis in neonates) with urinary infections in pregnant caused Chlamydia trachomatis.
In a review of the erythromycin it is indicated that the antibiotic often used for prevention of infectious complications in a variety of diagnostic and therapeutic procedures.
Erythromycin - Instructions for use
According to the instructions Erythromycin tablets should be taken orally (not chew). The daily dose for adults and adolescents (over 14 years) is 1-2 g, single - 0, 25-0, in '50, if necessary daily dose increased to 4, the interval between doses - six hours.
Children from four months to 18 years, depending on body weight, age and severity of illness appoint 0 0 03- 05 g / kg per day in two to four stages, the children of the first three months of life - 0, 2-0, 4 g / kg per day Erythromycin. If necessary, the daily dose is doubled.
In the treatment of diphtheria are taking erythromycin at 0, 25 grams of the drug twice a day.
The therapeutic dose for primary syphilis - 30-40 grams of antibiotic for the entire course of treatment. The course of treatment - one or two weeks.
In amoebic dysentery adults appoint 0, 25 grams of the drug four times a day, children - 0.03-0, 05 g / kg per day Erythromycin. Duration of the course - 10-15 days.
When legionella take on 0, 5-1 medication four times a day for two weeks.
In gonorrhea - at 0, 5 g of the drug every six hours for three days, then - 0, 25 g every six hours during the week.
To prevent infectious complications administered 1 g of antibiotic in 19 hours, 18 hours and 9 hours before the operation.
When pertussis take on 0, 04-0, 05 g / kg of the antibiotic a day for one to two weeks. When pneumonia in children - 0 05 g / kg of the antibiotic a day (in four stages). Duration of the course - at least three weeks.
When urinary infections during pregnancy - 0, 5 g medication four times a day for a week.
Erythromycin ointment applied to the affected area, as in eye diseases for a lower eyelid. Frequency, the dose and duration of application of erythromycin ointment set individually.
- hypersensitivity to any component of the drug;
- hearing loss;
- concomitant use of terfenadine, astemizole, or;
- hepatic insufficiency.
Erythromycin can pass through the placental barrier, entering the blood plasma of the fetus, where it reaches a concentration of 5-20% of the concentration in the mother's blood.
Side effects of the treatment of erythromycin occur infrequently. In a review of erythromycin it says that long-term use of antibiotic there is vomiting, diarrhea, nausea, jaundice.
Judging by the reviews, Erythromycin in some cases may cause allergic reactions.
Prolonged use Erythromycin promotes resistance thereto pathogens.
Symptoms of overdose of erythromycin: acute liver failure, hearing loss.
activated charcoal method, careful monitoring of the respiratory system. Gastric lavage is considered effective when taking a dose five times higher than the therapeutic dose.
Drug interaction Erythromycin
Antibiotics reduce the bactericidal effect of beta-lactam antimicrobials - cephalosporins, penicillin, carbapenem.
Erythromycin increases cyclosporine nephrotoxicity and pharmacological action of benzodiazepines.
One-time receiving erythromycin and terfenadine, astemizole or contribute to possible development of arrhythmias.
One-time taking the drug and dihydroergotamine, or non-hydrogenated ergot alkaloids leads to spasmodic narrowing of blood vessels.
Term and storage conditions
According to the instructions Erythromycin should be stored in a dry, dark place at a temperature no higher than 25 ° C.
Shelf life - two years.