Ekzifin - an antifungal drug. The active substance - terbinafine hydrochloride.
Available in a gel, cream, ointment, spray, solution for outdoor use, tablets for oral administration. At low concentrations Ekzifin has fungicidal effect against dermatophytes (Trychophyton mentagrophytes, Trychophyton rubrum, Trychophyton verrucosum, Trychophyton tonsurans, Trychophyton violaceum, Epidermophyton floccosum, Microsporum canis), as well as fungi (Candida albicans as well). Activity against yeast fungi, depending on the type of agent is fungistatic or fungicidal nature. Ekzifin mechanism of action is to inhibit fungal squalene epoxidase cell membranes, specific inhibition of sterol synthesis fungal cell, resulting in ergosterol deficiency occurs, the intracellular accumulation of squalene and fungal cell death. The drug does not affect the metabolism of hormones.
According to the instructions, Ekzifin used for:
- fungal diseases of the skin, nails (onychomycosis in the case do not apply the local form of the drug): trihofitii, athlete, microsporia rubrofitii, candidiasis of the skin, mucous membranes;
- multicolored lichen (used local forms ekzifin);
- heavy, common ringworm requiring systemic treatment.
According to the instructions ekzifin, the drug is contraindicated in case of hypersensitivity to terbinafine, pregnancy, lactation, under the age of 2 years, renal, liver failure, alcoholism, endocrine disease, inhibition of bone marrow hematopoiesis, tumors, vascular occlusive disease of the limbs.
The dosage for the tablet form ekzifin is 250mg once a day. The duration of treatment depends on the severity of the disease and the form and determined by the physician.
In hepatic and renal failure, the dosage is 150mg daily.
The local form of the drug with a thin layer applied to the affected area. The multiplicity of use - one - two times a day. Spray solution was applied to previously cleaned and dried portions.
The duration of treatment ekzifin at defeat nail plates long and depends on the rate of nail growth, usually 1-2 months. The optimal clinical effect is achieved within a few months after the complete mycological cure and cessation of therapy.
When candidiasis Ekzifin used inside only with widespread heavy defeat.
Children experience of ekzifin limited.
When using ekzifin account the following side effects:
- dyspeptic symptoms: nausea, loss of appetite, diarrhea, abdominal pain, feeling of fullness)
- Allergic reactions: rash, urticaria;
- musculoskeletal reactions: myalgia, arthralgia.
Very rarely taste disturbance, cholestatic jaundice, Stevens-Johnson syndrome, toxic epidermal necrolysis, agranulocytosis, thrombocytopenia, anaphylactoid reactions.
Side effects are often the cause of the negative reviews on ekzifin. For their prevention should be to respect the dosage, use the drug only on prescription, read the instructions before use to ekzifin.
In overdose ekzifin nausea, headache, gastralgia, dizziness. Treatment of non-specific: chelators in, symptomatic therapy.
Irregular use ekzifin or early termination of treatment increases the likelihood of recurrence of the disease. If use of the drug for two weeks does not improve the clinical picture must be re-define pathogen and its sensitivity to the drug. Before starting therapy, as well as during treatment should be monitored indicators of liver. If you have symptoms suggesting the oppression of the liver, it is necessary to cancel the drug.
Interaction with other drugs ekzifin
Ekzifin 20% reduces the clearance of caffeine. Drugs that induce microsomal liver enzymes, increase the clearance and ekzifin counterparts. Ethanol and other hepatotoxic drugs while receiving a ekzifin increase the risk of hepatic dysfunction.
Due to the high activity of the drug reviews ekzifin positive. The effectiveness of therapy toenail onychomycosis ekzifin at over 90%, onychomycosis brushes - 95%. In chronic dermatophyte efficiency reaches 80-95%.
Registered ekzifin following analogues: Atifin, Binafin, Lamisil, Lamitel, Lamikan, Mikoterbin, Mikonorm, Onihon, Tebikur, Terbizil, Terbized-Agio, Terbinafine, Terbiks, Terbinoks, Termikon, Terbifin, UNGUSAN, Tiga-sanovel, Fungoterbin, Ekziter, Tsidokan .