COMBINED - ear and eye drops for topical administration. This drug is widely used in ENT practice and in ophthalmology.

Release form of the drug combinations and the Duo

 Combinations used in infectious and inflammatory diseases of the eye and its appendages
 Drops of combinations available in flakonah- as a solution from colorless to yellow. One vial contains 1 ml of formulation of ciprofloxacin and dexamethasone 3 mg. Accessories: disodium edetate, bezalkoniya chloride, mannitol, hydrochloric acid, gidroksipropilbetatsiklodekstrin, water for injections.

Pharmacological action combinations Duo

The active ingredients of the drug ciprofloxacin and dexamethasone provides antimicrobial and anti-inflammatory action.

Ciprofloxacin has a pronounced activity against both reproducing and staying alone gram-negative bacteria. Dexamethasone - a synthetic glucocorticosteroid, acting as an anti-inflammatory and immunosuppressive agent. This feature reduces the permeability and capillary proliferation, local exudation, cellular infiltration and collagen deposition of fibroblast activity. Due to dexamethasone, combinations Duo is able to suppress the formation of scar tissue.

Experience with drops combinations shows that the active ingredient of the drug ciprofloxacin perfectly penetrates into the various tissues of the eye (except for the lens). The maximum concentration of the active substance there half an hour after the instillation into the anterior chamber of moisture. Dexamethasone is well into the conjunctiva and corneal epithelium.

The auxiliary component of the preparation ensures long preservation of the active component on the surface of the eye, increasing the duration of action and efficacy.

Indications drops combinations Duo

Under the instruction combinations used in infectious and inflammatory diseases of the eye and its appendages - acute and subacute conjunctivitis, keratitis, uveitis anterior blepharitis and other inflammatory diseases of the century. Drops of combinations can be used for the prevention and treatment of infectious complications after operations on the eyeball or after an eye injury and its appendages.

Drops combinations can also be used in infectious and inflammatory diseases of the ear - acute otitis externa, acute otitis media in the shunt eardrum, acute otitis media with otorrhea and granulation in the presence of a shunt eardrum.

Combinations - Instructions for use

When an infectious-inflammatory processes in the cavity of the eye and its appendages one or two drops instilled combinations in the conjunctival sac every four to six hours. On the first day of treatment instillation may be repeated every two hours.

According to the instructions in the combinations blepharitis, bacterial conjunctivitis are recommended from five days to two weeks, with keratitis - from two to four weeks. For prevention of postoperative inflammation including perforation eyeball - from five days to one month. If this drug is used for more than ten days, should conduct monitoring of intraocular pressure of the patient.

When infectious and inflammatory diseases of the ear is necessary to dig into the ear canal of the affected ear combinations of four drops twice a day for a week.

Before burying means auditory canal must first be rinsed and drained. Before instillation of the drug is necessary to warm to body temperature. Then lie down and tilt the head to facilitate instillation. Dripped into the ear canal the required number of drops and give them to drain, pulling the earlobe down and back. Prior to the full penetration of droplets within a minute you can not change the position of the head.

Contraindications to the use of combinations Duo

Drops combinations can not be used in herpetic keratitis and other viral lesions of the conjunctiva and cornea, the eye of tuberculosis, fungal eye disease, viral infections, ear canal, eardrum perforation. According to the instructions duo combinations should not be used in children under 18, as well as in case of hypersensitivity to the active component, or to any of the ancillary components of the drug during pregnancy and breastfeeding.

Side effects combinations Duo

 COMBINED - ear and eye drops for topical use
 Instill drug combinations for a long time may cause redness, itching eyes, swelling of the veins, to blurred vision, as well as the narrowing of the visual field and reduced visual acuity. Drops combinations with prolonged use may promote the formation of cataract, conjunctival hyperemia. With prolonged use of funds to the underlying disease can join secondary infection (bacterial or fungal).

With instillation of the drops into the ear canal might develop discomfort in the ear, ear stuffiness. Sometimes instillation of the drug slows down wound healing, there is swelling of the face and skin rashes, taste perversion.


Long-term use of eye drops is sometimes accompanied by an increase in intraocular pressure. Increased intraocular pressure can be accompanied by a decrease in field and visual acuity, optic nerve damage, cataract formation. Therefore, when using the combinations Duo more than ten days is recommended to control intraocular pressure. When purulent infections in acute corticosteroid drugs can significantly impair or conceal the main symptoms of the disease.

After using the eye drops are sometimes reduced sharpness of vision. So after instillation of the drug should not be driving. Contact lenses can be worn only after twenty minutes after instillation of the drops.

Conditions and terms

Drops combinations stored at a temperature not exceeding 25 ° C. Shelf life - two years. The product after opening the bottle should be used within a month.