Diltiazem - anti-arrhythmic agent.

Pharmacological action

Diltiazem - a calcium antagonist, a drug that reduces the speed of the drive without affecting heart rate, preventing cardiac arrhythmia (supraventricular tahirkardiya).

Product form

Produce Diltiazem as a solution for injection, tablets and capsules of conventional and long-acting (Diltiazem lannaher).


Diltiazem is indicated in the instructions for arterial hypertension in patients with angina pectoris and myocardial infarction in cases where contraindicated use of beta-blockers; in patients with diabetic nephropathy in case of impossibility of using ACE inhibitors; Prinzmetal angina and stress; for the prevention of coronary spasm during coronary artery bypass grafting or coronary angiography.

Diltiazem is administered intravenously at a supraventricular arrhythmia, atrial flutter, atrial fibrillation, arrhythmia; for the relief of paroxysm of atrial fibrillation.

Good reviews of Diltiazem, used for pulmonary hypertension.

Instructions for use Diltiazem

Diltiazem as antianginal, antihypertensive take 3-4r / day. of 30mg.

Diltiazem lannaher begin to take on the two rows of 60-120mg / day or 180-240mg one p / day. correction-dosage two weeks. The day is allowed to take no more than 360mg.

Diltiazem Tablets according to instructions taken before meals, they can not chew.

For relief of supraventricular tachycardias intravenously administered two minutes 0, 15-0, 25 mg per kilogram of body weight.

In order to restore sinus rhythm, connect 120mg and 160mg of the drug propranolol (action manifest for 20-40min.).

 Diltiazem lannaher
 In order to prevent attacks of supraventricular tachycardia introduced 240-360mg per day.

For the treatment of permanent form of atrial, atrial fibrillation Diltiazem (up to 240 mg / day) is connected to the cardiac glycosides.

For the treatment of pulmonary hypertension take up Diltiazem 720mg per day.

side effects

Diltiazem may cause negative reactions on the part of different systems:

  • cardiovascular and blood: transient hypotension, reduction of cardiac volume conduction disturbances 1st degree, fainting, palpitations, eosinophilia, bradycardia;
  • nervous, sensory organs: weakness, dizziness, headache;
  • gastrointestinal tract: nausea, heartburn, diarrhea, constipation, and other symptoms of dyspepsia, gingival hyperplasia mucosa (rare);
  • skin redness, sweating, allergic pruritus, rash, erythema multiforme exudative (rare);

There are reviews of Diltiazem, that after its use in patients exhibiting increased transaminases, there were peripheral edema.

In some cases were reported hyperglycemia, impaired potency.


Diltiazem is contraindicated in severe bradycardia, hypersensitivity syndrome WPW, cardiogenic shock, AV blockade 2-3st., Arterial hypotension, heart failure, chronic 2B-3st., Acute cardiac insufficiency, severe impairment of renal, hepatic functions, during lactation, pregnancy.

Prohibited designation Diltiazem children.