Creon 10000

Creon - enzyme preparation used in disorders of the digestive processes, as well as for the treatment of cystic fibrosis in children.

Pharmacological action

Active ingredients Creon - pancreatic enzymes, improve the digestive processes, facilitating the digestion of proteins, carbohydrates, fats, which leads to a more complete assimilation of them.

Creon dissolves rapidly in the stomach, releasing minimicrospheres containing enzymes of animal origin, amylolytic, lipolytic and proteolytic activity, which, mixing with the intestinal contents contribute to a better distribution and lead to a disintegration of molecules of fats, starch and lipids.

In the opinion of Creon, the drug was well tolerated by both adults and children.

Product form

The drug is released in the form of hard gelatin enteric capsules with a transparent body containing a different quantity of active ingredient - pancreatin:

  • Creon 10,000 - contains 150 mg of pancreatin; 10 and 25 in the blister units, and 50 to 20 pieces in polypropylene vials;
  • Creon 25,000 - contains 300 mg of pancreatin; 10 and 25 in the blister units, 20, 50 and 100 pieces in polypropylene vials;
  • Creon 40,000 - contains 400 mg of pancreatin; 20, 50 and 100 pieces in polypropylene vials.

The contents of capsules - minimicrospheres enteric beige. Excipients - hypromellose phthalate, macrogol 4000, cetyl alcohol, dimethicone 1000, triethyl citrate.

Indications Creon

According to the instructions Creon is used as replacement therapy in the failure of exocrine pancreatic function:

  • Chronic pancreatitis;
  • Pancreatic cancer;
  • Shvahmana Diamond Syndrome;
  • Fermentobrazuyuschey reducing the gastrointestinal tract in the elderly;
  • Cystic fibrosis;
  • Ductal obstruction due to tumors;
  • Pancreatectomy.

For the symptomatic treatment of Creon instructions apply for violations of the digestive processes:

  • Total gastrectomy;
  • Biliary obstruction;
  • Cholestatic hepatitis;
  • Condition after cholecystectomy;
  • Partial gastrectomy;
  • Pathologies of the terminal portion of the small intestine;
  • Bacterial overgrowth in the small intestine;
  • Duodeno- and gastrostasis;
  • Cirrhosis of the liver.

Also for children Creon often prescribed in the recovery period after diarrhea.


According to the instructions Creon is contraindicated during exacerbation or acute pancreatitis, and if you are hypersensitive pancreatin of porcine origin or to other components of the drug.

Also Creon should not be used in the early stages of pancreatitis.

When using Creon children for a long time, you must undergo regular monitoring by a specialist.

To eliminate the possible defeat of the colon when using Creon, especially at high doses, should be monitored for the appearance of unusual symptoms in the abdomen.

Instructions for use of Creon

 Creon 25000

Creon is used while eating, swallowing the capsule whole. Half or a third of a single dose is recommended to take immediately before the meal, and the rest - during meals.

The dose of Creon instructions determined individually, depending on the disease and the applied diet using Creon in different dosage -10000, 25000, or 40000.

In cystic fibrosis Creon initial dose for children up to 4 years is 1000 units of lipase per 1 kg, for children older than 4 years - 500 lipase per 1 kg. Creon is used during each meal, both primary and secondary. For children typically used Kreon 10000. In case of difficulty swallowing the capsules, you can open and contained therein minimicrospheres add liquid foods with acidic pH & lt; 5. Such a mixture is made immediately before the reception, because it can not be stored.

When pancreatic insufficiency with different nosologies dose is determined depending on the inspection results steatorrhea and severity of symptoms in order to maintain 10 000 IU of lipase per 1 kg a day.

Creon dose can vary from 20,000 to 75,000 units of lipase during the main meal, and while taking a light meal - from 5 000 to 25 000 units of lipase.

Also, to prevent the strengthening of constipation is necessary to ensure constant fluid intake sufficient.

In the opinion of Creon in overdose can cause hyperuricemia and giperurikuriyu. In this case you need to cancel Creon and spend symptomatic therapy.

Application Creon during pregnancy and lactation has not been investigated, so you can only use the drug by the physician.

Side effects

In the opinion of Creon side effects is very rare. There may be changes in stool, diarrhea, nausea, abdominal pain.

When using Creon children sometimes appear minor skin reactions.

Storage conditions

Creon 10000 and 25000 sold without medical prescription, Creon 40000 - prescription. Shelf life Creon 10000 - 2 years, Creon 25,000 and 40,000 vials - 3 years. Opening the bottle to keep no more than six months.