Coraxan - agent for the treatment of cardiovascular diseases.
The active substance Coraxan - ivabradine, which is a selective blocker of the specific sinus node.
Effect of the drug is to suppress the if-channels, which normalizes the heart rate.
It affects ivabradine specifically on myocardium - only sinus node without affecting the reduction of infarction, ventricular repolarization of heart, pulse transit time intraatrial, predserdnozheludochkovym, intraventricular routes.
There are reviews of Coraxan, that the decrease in heart rate in the recommended dosage reaches 10 beats / min under load or at rest. Because of the impact on Coraxan heart rate may decrease oxygen demand myocytes and load on the myocardium.
The product is produced in tablets. As an analogy, you can use drugs Coraxan ivabradine ivabradine hydrochloride.
According to the instructions Coraxan used to treat angina, stable with good sinus rhythm with contraindications (including hypersensitive) to the use of beta-blockers (which is why drug treatment often recommended as an alternative).
According to the instructions Coraxan not be prescribed when severe liver failure, patients with heart rate up 60ud / min., With a marked reduction in pressure in acute myocardial, weakness of sinus node, sinoatrial blockade, implantation of artificial rhythmic driver, atrioventricular blockade of the third degree, unstable angina, chronic heart failure, hypersensitivity, cardiogenic shock.
You can not simultaneously receive azole antifungals Coraxan a group (ketoconazole, itrokonazol), HIV protease inhibitors (nelfinavir, ritonavir), macrolide antimicrobial drugs (erythromycin for oral administration, telithromycin, josamycin, clarithromycin, nefazodone).
Use analogues Coraxan only intended attending physician - the active substance in the same preparations, there may be the same side effects and contraindications.
Instructions for use Coraxan
There are only internal use Coraxan, during meals. The daily dose is usually divided into two doses, drink tablets in the morning and evening.
Started treatment with a single oral 5 mg two rows / day. Depending on the outcome of treatment in 3-4ned. to increase the dose of one tablet 7, two rows of 5mg / day.
Dosage reduction Coraxan used if the patient shows signs of bradycardia (dizziness, hypotension, fatigue), decrease in heart rate to 50 beats / min or less.
If after a dose reduction of heart rate is not normal, stop the use of Coraxan.
For the treatment of patients older than 75l. therapy begins with 0, 5tabletki (2, 5 mg) two p / day. Permissible dose - 5 mg per day. If there is a stable state of the patient, the dose is adjusted to a standard level specified in the instructions Coraxan.
Patients with renal failure Coraxan normally prescribed dosage. If the rate of creatinine clearance prevyshaet15ml / min, these patients Coraxan used with caution.
Analogs Coraxan may apply to other schemes, should be familiar with their instructions.
Reviews Coraxan about side effects caused by the drug are based on clinical trials, 5000 patients, 2900 of whom received ivabradine.
For part of the vision of frequent violations svetovospriyatiya (photopsias). It was recorded as an increase in the level of serum creatinine, hyperuricemia, eozionofiliya, the emergence of constipation, diarrhea, nausea.
In the first two or three months the application of the subjects Coraxan patients manifest severe bradycardia - 40 beats / min or less. Fixed ventricular arrythmia, block 1st degree atrio-ventikulyarnaya, supraventricular beats, palpitations.
By the way emergent side effects include Coraxan shortness of breath, headache, muscle cramps and dizziness. Headache Pain often appears at the beginning of treatment, in the first month. Her and dizziness associated with a decrease in heart rate.
Reviews Coraxan point to the fact that the following conditions have developed in patients taking the drug and those who did not accept the means: sinus arrhythmia and atrial, unstable angina, ventricular tachycardia, myocardial ischemia and infarction, worsening of angina.
There is an assumption that these side effects did not develop as a response to Coraxan and were provoked by the primary disease.