Co-renitek - antihypertensive combination drug used to treat hypertension.

Pharmacological action

The active ingredients have a Co-Renitec diuretic and antihypertensive effect.

Enalapril - angiotensin-converting enzyme, reducing blood pressure, increased renal blood flow, leading to regression of hypertrophy and preserve left ventricular systolic function, a positive effect on the ratio of the fractions of lipoproteins and total cholesterol.

Improvement occurs both standing and supine without a strong increase in heart rate. Hydrochlorothiazide, increases the activity of renin, which results in a greater pressure reduction. Co-renitek a convenient dosage form for the joint appointment of enalapril and hydrochlorothiazide.

Co-Renitec advantage over monotherapy is more pronounced effect and the duration of its effect. Co-exposure renitek starts within an hour after ingestion, and the maximum pressure is reduced after 5-6 hours. Duration of exposure depends on doses received, on average during the day.

If necessary, you can pick up analogues Co-Renitec having the same chemical composition.

Product form

Ko renitek produced in the form of yellow circular milled edge tablets containing 12, 5 mg of hydrochlorothiazide and 20 mg of enalapril maleate. Excipients - lactose water, sodium bicarbonate, corn starch and corn pregelatinized, magnesium stearate, yellow iron oxide colorant. 7 pieces in a blister pack and 56 pieces in plastic bottles.

Indications Co-renitek

Co-renitek according to the instructions is used for treating high blood pressure in the possibility of using combination therapy.


According to the instructions of Koh renitek contraindicated in case of hypersensitivity to sulfonamide derivatives and the components of the drug, anuria and angioedema in history.

Application Co-Renitec during pregnancy, especially during the second and third trimester and during lactation is contraindicated.

Be wary appointed Co-renitek at:

  • Diabetes;
  • Chronic heart failure;
  • Condition after kidney transplantation;
  • Bilateral renal artery stenosis;
  • Suppression of bone marrow hematopoiesis;
  • Coronary heart disease;
  • Renal or hepatic impairment;
  • Aortic stenosis.
  • Cerebrovascular diseases, including cerebrovascular insufficiency;
  • Severe autoimmune systemic connective tissue diseases, including scleroderma, and systemic lupus erythematosus;
  • Stenosis of the artery to a solitary kidney;
  • Hyperkalemia.

Ko renitek by instructions prescribed with caution to patients of advanced age, during restricted sodium diets, as well as children, due to lack of clinical studies.

Instructions for use Co-renitek

P  Co-renitek pills
 Manual Ko renitek can be taken regardless of meals. Initial dose - one tablet per day, if necessary, can be doubled.

When violations of water-electrolyte balance caused by previous treatment with diuretics, sometimes progressing to symptomatic hypotension. Therefore, a few days before taking Co-Renitec should stop taking diuretics.

With an overdose of Co-Renitec under the instruction may develop severe hypotension, stupor, and strengthening other side effects.

In the application of Co-Renitec with other antihypertensive agents may increase the effect. In applying the drug in renal impairment is possible reversible further deterioration of their functions.

side effects

According to the instructions of Koh renitek causes side effects are not common.

Occasionally you may experience hypotension, syncope, chest pain, palpitations, and tachycardia. Also Co-renitek can cause fatigue, dizziness, cough, impotence. Rarely appear insomnia, vertigo, drowsiness, shortness of breath, artalgiya, skin rash, rash, abdominal pain, constipation, diarrhea, dry mouth, and gout.

There are other drugs that are analogues Co-Renitec. This combination preparations containing the same active ingredients, but in different proportions. Full analogue of Co-Renitec is Enap HL 20, but other drugs such as Renipril GT, Enap-H, enalapril NL-Acre, Acre Enalapril H Enafarm-H, also have an antihypertensive effect.

storage conditions

Co-renitek assigned to B and the list released by the doctor's prescription.

Shelf life of the tablets in bottles - 2 years in blisters - 3 years.