Clonidine - hypertensive drug used for the relief of hypertensive crises, the treatment of hypertension and glaucoma.

Mode of action of clonidine

The active ingredient Clonidine has a strong hypotensive and sedative effect.

The action of clonidine occurs simultaneously with a decrease in peripheral vascular resistance, including renal vessels, lowering intraocular pressure and reduced cardiac output. Sometimes resistant pressure reduction may precede short-term (a few minutes) hypertensive effect.

Clonidine has an effect in very small doses, it acts rapidly and long. Sustained effect manifested several hours after administration, and the duration - up to eight hours. Clonidine may potentiate their hypotensive effect and cause fairly severe side effects, including death, in combination with certain drugs and alcohol, in connection with what Clonidine without a prescription does not release.

Product form

Clonidine produced in the form:

  • In a solution of 0, 01% in 1 ml ampoules;
  • Pills and tablets of prolonged action on 0, 15 and 0 mg, 075 mg;
  • In a solution of 0 5% 0 25% and 0% to 125 tubes of the dispenser applied as eyedrops.


According to the instructions Clonidine is widely used in various forms of hypertension, and also for the relief of hypertensive crisis.

In ophthalmic practice Clonidine is used for medical treatment of patients with primary open-angle glaucoma.

Clonidine is also on the instructions used to reduce symptoms of alcohol or drug withdrawal due manifested sedative and analgesic effect. The drug reduces the feeling of fear and other disorders caused by abstinence.

Instructions for use and dosage of clonidine

According to the instructions Clonidine is used subcutaneously, orally, intravenously and intramuscularly. In ophthalmology - in the form of installations directly into the eye.

The doses of clonidine are selected strictly individually.

As the antihypertensive agent is usually administered in the form of tablets, to 0, 075 mg of 2 to 4 times per day. With little effect single dose of clonidine can be increased every 2 days at 0, 0375 mg to 0, 15-0, 3 mg per reception, the multiplicity of up to 3-4 times a day.

Daily doses of clonidine may vary from 0 to 1 to 3 mg, 5 mg, depending on the disease. To enhance the effect, often at the same time taking Clonidine saluretikami, methyldopa, reserpine and other antihypertensive drugs.

Patients elderly and middle-aged at displays sclerosis of brain vessels, due to possible hypersensitivity to clonidine, treatment is initiated with the lowest dose - 0, 0375 mg. The duration of treatment depends on the effectiveness of treatment and may range from a few weeks to a year, and in some cases even longer.

In cases when hypertensive crises and high pressure applications inside is not effective, Clonidine is used subcutaneously, intramuscularly or intravenously.

When administered intravenously, the drug is administered slowly over 3-5 minutes. In this case, the hypotensive effect is almost immediately, after 3-5 minutes, reaching a maximum in 15-20 minutes.

In severe cases, the patient treatment conditions clonidine administered parenterally solution 3-4 times a day, subject to bed rest for at least 2 hours after administration.

 Clonidine pills
 Clonidine is also sometimes used in heart failure and for the relief of pain in acute myocardial infarction.

In glaucoma, the drug is used as a topical instillation into the eye, 0, 5%, 025%, or 0 125% solution to 4 times per day. With effective treatment, and a stable state of the field of view of Clonidine can be used for a long time, more than a year. In the absence of the effect in the first few days of treatment, Clonidine overturned.


Clonidine for instructions contraindicated for use in the form of eye drops in patients with severe cerebral arteriosclerosis and hypotension.

In the application of clonidine can not engage in activities requiring attention and quick response.

Do not use this Clonidine with alcohol. With simultaneous use of the drug causes a sharp decrease in pressure, drowsiness and deepens the disruption of the heart. These reactions to the combined use of clonidine with alcohol are well known and often used in the criminal world for personal gain. In a series of poisonings in the 90s of the last century, clonidine poisoning occupied a leading place in mind accessibility, ease of use and low cost of the drug. Under certain circumstances Clonidine with alcohol can cause death. Therefore Clonidine counter in pharmacies are not released.

Side effects of clonidine

According to the instructions Clonidine can cause drowsiness and fatigue, dry mouth.

When large doses of clonidine may be constipation and a sharp drop in blood pressure on changing position of the body. The rapid rise of pressure is often seen with a sharp lifting of the drug.

When using a solution of clonidine in ophthalmic practice may also experience a decrease in pressure and slow pulse.

storage conditions

Clonidine without a prescription does not release and is related to drugs list B.