International name: citalopram.


The active ingredient - citalopram hydrobromide.  Cipramil tablets
 As auxiliary substances used are: glycerol 85%, corn starch, croscarmellose sodium, lactose monohydrate, microcrystalline cellulose, copovidone, magnesium stearate.

Sheath: Macrogol 400 gipromelloza5, titanium dioxide (E 171).

Pharmacological action tsipramil

Cipramil - an antidepressant, selective serotonin reuptake inhibitor.


Cipramil has a very mild ability to bind to receptors, including muscarinic, histamine and adrenergic receptors.

Cipramil very slightly inhibits cytochrome P450IID6 and thus does not interact with drugs metabolized by this enzyme. Cipramil no effect on blood pressure, on the conducting system of the heart, on hematological parameters, as well as kidney and liver function. Antidepressant effect tsipramil develops in about 2-4 weeks of regular admission. Adoption of the drug does not contribute to weight gain.


After the internal use of the drug bioavailability of citalopram is about 80%. The level of the maximum plasma concentration achieved poproshestvii 2-4 hours after ingestion. Metabolism occurs by demethylation, oxidation and deamination. Constant level of plasma concentration is set within 1-2 weeks of regular treatment. The half-life is 36 hours. Return with urine and feces.

Indications tsipramil

Used to treat depression and etiology of various structures in adult patients as well as in the treatment of panic and obsessive-kompulsivnyhrasstroystv.


Cipramil is contraindicated in persons with hypersensitivity to citalopram or to any of the excipients used.

Should be avoided tsipramil combined with inhibitors of monoamine oxidase including within 14 days after completion of reception.

According to the instructions Cipramil treatment for pregnant and lactating women is possible only on the basis of comparing the likely benefits for mothers with probable injury to the child. Studies on the safety of receiving tsipramil during pregnancy and lactation has not been carried out.

Dosage tsipramil and instructions for use

The drug is administered once at any time, regardless of the meal.

In the treatment of depression: assigning 20 mg per day. If necessary, the dose may be increased to 60 mg / day.

In the treatment of panic disorder, during the first week prescribed 10 mg per day, then the dose increased to 20 mg. If necessary, the dose may be increased to 60 mg / day.

For patients older than 65 years, the recommended dose is 20 mg per day, with a possible increase to 40 mg per day. Patients with hepatic impairment is recommended to take the drug in small doses, the maximum dose of 30 mg per day. In mild and moderately severe kidney failure does not require dose adjustment.

Side effects tsipramil

Side effects of the drug wear transistor and bland character may occur in the first weeks of treatment, with the improvement of the patient's condition weakened. In tsipramil and analogs side effects may manifest as: dry mouth, drowsiness, nausea, weakness, diarrhea, sweating, tremor, insomnia, sexual dysfunction.  Cipramil in the package

According to the feedback received Cipramil therapy can cause a slight reduction in heart rate. In patients with a low heart rate reception Cipramil can cause bradycardia.

Very rarely when using large doses may cause seizures.


These overdose Tsipramilom reviews indicate the probability of the following symptoms:

  • drowsiness;
  • violation of articulation;
  • coma;
  • increased sweating;
  • sinus tachycardia;
  • nausea and vomiting;
  • hyperventilation;
  • cyanosis.

There is no specific antidote, symptomatic lechenie.Posle recommended oral dosing gastric lavage is recommended to do as quickly as possible.

Interaction with other drugs tsipramil

About chemical incompatibility tsipramil reviews have been received. Combining tsipramil monoamine oxidase inhibitors may cause hypertensive crisis.

Not applicable tsipramil interaction with alcohol, but drinking alcohol during treatment is not recommended. In clinical trials there was no evidence of pharmacodynamic interaction with cardiotropic drugs.


Patients receiving therapy with antidepressants, need careful medical supervision, especially at the beginning of the course, because of the likelihood of clinical worsening and suicidal symptoms.

The use of selective serotonin reuptake inhibitors in the third trimester of pregnancy may have a negative effect on the psychological and physical development of the child. In children whose mothers took during pregnancy Cipramil, registered the following disorders: tremor, irritability, hypertension, tearfulness, increased muscle tone, poor sleep. These disorders can occur as a result of withdrawal. When using analog tsipramil pregnant should not be abrupt withdrawal.

Persons carrying out potentially dangerous work, care must be taken during the period of treatment.

Keeping drug Cipramil

Store at temperatures up to + 30 ° C, out of reach of children.

Shelf life tsipramil

5 years.