Chloral hydrate - refers to a group of medicines that affect the central nervous system.
The pharmacological action of chloral hydrate
Chloral hydrate has
hypnotic, analgesic, anticonvulsant and sedative effect. In large doses, it has narcotic properties. On the central nervous system Chloral hydrate has a complex effect. In the appointment of small doses of the drug reduces the inhibitory processes, and in high doses reduces the excitation processes. It is dangerous to use a high dose of chloral hydrate is too close to toxic, because they strongly inhibit the process of nerve cell excitability.
Chloral hydrate has a pronounced irritant effect on the mucous membrane of the stomach and intestines, so it should only be diluted with the enveloping means.
Chloral hydrate is rapidly absorbed. Sleep close to physiological sleep, after about 15 minutes and lasts for eight hours.
Indications for use of chloral hydrate
According to the instructions Chloral hydrate is used for the relief of mental excitement, convulsions in children, when spazmofilii, tetanus, rabies, eclampsia. Chloral hydrate can be used for restless children and adult patients of certain types of research, requiring a fairly long standstill (MRI, CT).
Chloral hydrate: instructions for use
Adults Chloral hydrate is appointed by mouth or in the form of enemas at a dose of 0, 2-1, 0 g per reception. The drug is taken only in conjunction with the enveloping means and in a large dilution.
Babies with chloral hydrate administered in the dosage depending on the age, ranging from 0 05 to 0, '75
The highest single dose of chloral hydrate for adults - two grams, and daily - six grams.
Acceptance of chloral hydrate may be accompanied by a decrease in blood pressure and vomiting.
Long-term use of the drug often leads to the development of drug dependence (hloralomanii).
According to the instructions Chloral hydrate can not be used to treat patients with severe diseases of the cardiovascular system, kidneys and liver. Other contraindications to chloral hydrate are:
• Alcohol or drug dependency at present or in history;
• esophagitis, gastritis, peptic ulcer disease (when administering the drug orally);
• proctitis, colitis (in the appointment of an enema);
• intermittent porphyria.
Chloral hydrate should
with very great care given to pregnant women. With its long-term use in newborns can be observed withdrawal.
The drug penetrates well into the breast milk and cause infants sedation. Therefore, if necessary, use of chloral hydrate breastfeeding should be discontinued.
No specific antidote. Treatment of symptomatic poisoning: gastric lavage, maintenance of respiration and circulation at a normal level, forced diuresis. In severe poisoning shown hemodialysis.
Admission chloral hydrate together with other drugs, providing a depressing effect on the central nervous system and alcohol, is not valid.
Product form chloral hydrate and storage conditions
Chloral hydrate produced in the form of tablets containing 0, 5, 0, 75 and 1, 5 g of the active substance. The package - 10 tablets.
The drug belongs to the list B. It should be stored at room temperature in a dry and dark place, away from children. Shelf life - 8 years.