Cefazolin - semisynthetic  Packing Cefazolin
 an antimicrobial drug. Reviews of cefazolin confirm its high antibacterial efficacy.

Ifizol, Lizolin, Cefazolin "Biohemi" Orizolin, Natsef, Antsef, Cefazolin-ICCO, Tsefamezin, Tsefezol, Cefazolin-Verein, Tsezolin, Cefazolin Elf Cefazolin Sandoz, Tsefoprid - drugs cefazolin counterparts.

Structure and Composition of cefazolin

Cefazolin is available as a powder for solution for intramuscular or intravenous injection (vials for 0, 5, 1 and 2 g). Cefazolin sodium salt - antibiotic active component (500, 1000. 2000 mg, respectively, in one vial).

Pharmacological action

Cefazolin - the least toxic cephalosporin antibiotic with a broad spectrum bactericidal action.

According to the instructions Cefazolin is active against gram-positive bacteria (Staphylococcus spp., And synthesizing are not synthesized penicillinase, Streptococcus spp., Including Corinebacterium dlphtheriae, pneumococci), Gram-negative microorganisms (Proteus mirabilis, Salmonella spp., Enterobacter aerogenes, Escherichia coli, Neisseria gonorrhoeae, Shiqella spp, Klebsiella spp., Haemopnylus influenzae, Neisseria gonorrhoeae). Resistance to the drug fungi, rickettsia, protozoa, viruses, indolpolozhitelnye strains of Proteus (P.rettgeri, P.vulgaris, R. morgani).

The maximum drug concentration achieved one hour after intramuscular injection and immediately - after intravenous administration. According to the instructions in the therapeutic concentration of cefazolin (90% of the administered dose) remains in the blood for 8-12% chasov.90 medication excreted by the kidneys unchanged.

Cefazolin - indications for use

According to the instructions the use of cefazolin is shown in the following infectious diseases:

• pneumonia, lung abscess, empyema;

• peritonitis, endocarditis, osteomyelitis, burns, wound infections;

• infectious and inflammatory processes in the urinary tract;

• soft tissue infections;

• skin infection;

• infection osteoarticular system;

• prevention of postoperative complications.

Dosing cefazolin

According to the instructions on indications Cefazolin is administered intravenously or intramuscularly (bolus or infusion).

For intramuscular injection of an antibiotic solution prepared ex tempore, spreading the contents of one vial of 5 ml of sterile water for injection or isotonic sodium chloride solution. The drug is injected deep into the muscle tissue.

For intravenous bolus injections of a single dose of an antibiotic is diluted in 8-10 ml of isotonic sodium chloride solution. The antibiotic should be administered very slowly (over 4-5 minutes).

When intravenous drip drug (500 - 1000 mg) were diluted in 5% glucose solution or in 150-250 ml of isotonic sodium chloride solution. Cefazolin should be administered within an hour (introduction rate - 65-80 drops per minute).

The daily dose of the antibiotic for adults - from 1000 mg to 4000 mg. The daily dose depends on the susceptibility to the drug and the severity of the infection. A single dose of the drug for adults with infectious-inflammatory processes caused by Gram-positive microbe, is 250-500 mg every eight hours.

When infectious respiratory diseases of moderate severity caused by pneumococcus, and infectious and inflammatory processes in the urinary tract appoint 500 - 1000 mg of the drug every twelve hours.

In infections caused by Gram-negative bacteria, the antibiotic prescribed for 500 - 1000 mg every seven to eight hours. In severe infections (peritonitis, necrotizing pneumonia, septicemia, endocarditis, hematogenous osteomyelitis in acute, urinary tract infection), the daily dose of cefazolin may be increased to 600 mg (maximum). The interval between injections - six to eight hours.

Children over months of drug administered in a daily dose of 20-50 mg / kg body weight (in divided doses) when very severe infections, 100 mg / kg.

The use of cefazolin adults with impaired renal function is carried out on the adjusted scheme (with an increase in the intervals between injections and gradual reduction of the dose of the antibiotic).

The daily dose of the antibiotic  Cefazolin in the bottle
 Children with moderate impaired renal excretory function is 60% of the standard daily dose of cefazolin.

The daily dose of the drug with significant renal dysfunction - 10% of the standard dose. The interval between injections - not less than one day.

Contraindications to the use of cefazolin

• hypersensitivity to cephalosporin drugs;

• lactation;

• Children under the age of one month;

• pregnancy.

Side effects of cefazolin

The feedback to cefazolin stating that prolonged use of antibiotics often causes diarrhea, vomiting, tachycardia, nausea, allergic reactions - fever, pruritus, urticaria, Stevens-Johnson syndrome.

In rare cases, prolonged use of cefazolin leads to renal failure, hemolytic disorders.

There are reviews of cefazolin, confirming that the intramuscular injection of antibiotics is often painful and can cause induration at the injection site.

Drug Interactions

One-time use of cefazolin and "loop" diuretics leads to the blockade of tubular secretion of an antibiotic.

The combined use of cefazolin ethanol contributes to disulfiramopodobnyh reactions.

The combined use of cefazolin and probenecid in the complex therapy leads to disruption of excretion of the antibiotic.

storage conditions

Store in a cool, sheltered from sunlight, at a temperature of not less than 25 ° C.