Carboplatin - anticancer drug used in mono- and combination therapies in treating cancer.
Carboplatin is produced in the form of a sterile lyophilized powder for injection in vials of 50 mg, 150 mg, 200 mg and 450 mg (Carboplatin 450) and as a solution for injection in ampoules of 5, 15 and 45 ml. An analogue of the drug - carboplatin Teva.
The active substance having antitumor effect of carboplatin by exposing the DNA by heavy metal - platinum, resulting in death of cancer cells.
Carboplatin is used in a variety of cancer:
- Lung cancer;
- Bladder cancer;
- Head and neck tumors;
- Ovarian cancer;
- Osteogenic sarcoma;
- Testicular germ cell tumors and ovarian cancer;
- Malignant melanoma;
- Cancer of the cervix and uterus.
Carboplatin Teva is contraindicated in severe renal impairment and increased sensitivity to drugs that contain platinum, and in the case where the treatment was preceded by severe blood loss or a substantial mielodeprescia.
Carboplatin is used with caution varicella, herpes zoster and other acute infectious diseases.
With caution used carboplatin Teva after the course of radiation therapy.
Carboplatin is contraindicated in pregnancy and lactation. The drug has fetotoxic effects, so women of childbearing age should use reliable contraceptive measures.
Instructions for use Carboplatin
The dose and treatment regimen of carboplatin is determined individually, depending on:
- The states of the hematopoietic system;
- Stage of the disease;
- Scheme antitumor therapy.
As a single agent carboplatin 450 most frequently used to treat ovarian cancer.
Carboplatin and Paclitaxel used in the complex chemotherapy. The greatest number of combinations of these drugs research conducted for the treatment of lung cancer, because lung cancer has a very high mortality rate.
Combined therapy of carboplatin and paclitaxel is currently the standard of palliative chemotherapy because of the convenience of outpatient use and acceptable toxicity profile. The effectiveness of this method of treatment is 68-80%.
Carboplatin is used only under the supervision of an experienced physician chemotherapist, monitoring during treatment picture of peripheral blood, kidney function and neurological status.
Carboplatin 450 can cause various side effects:
- Leukopenia, anemia and thrombocytopenia;
- Vomiting, anorexia, nausea, constipation or diarrhea and abnormal liver function;
- Peripheral polyneuropathy and hearing loss and vision;
- Urticaria, bronchospasm, skin rash, hypotension;
- Amenorrhea and azoospermia;
- Alopecia, renal dysfunction, pain at the injection site, fever.
Carboplatin is available on prescription. Shelf life - 3 years.