Bisogamma (int. References. - Bisoprolol) - The drug belongs to the group of selective beta-blockers and is used to treat hypertension.

Structure and Composition

According to the instructions, Bisogamma available as tablets (5 mg and 10) which are coated with a film coating.

One tablet contains bisoprolol (5 and 10 mg, respectively) and excipients (prozhelatinizirovanny starch, crospovidone, microcrystalline cellulose, colloidal silica, macrogol, magnesium stearate, titanium dioxide, talc, hypromellose, dye, iron oxide yellow).

Pharmacological action Bisogamma

The drug has hypotensive (lowers blood pressure), antiarrhythmic and antianginal (analgesic) effect.

Bisogamma as selective beta adrenolokator reduces plasma renin activity, slows the heart rate, reduces the need for cardiac muscle for oxygen.

In the opinion of Bisogamma (the treatment of hypertension) gives the hypotensive effect after 2-5 days of treatment, a steady decrease in blood pressure occurs in 1-2 months.

Antianginal effect is associated with a decrease in the need of the heart muscle (myocardium) due to deceleration heart rate. The antiarrhythmic effect is due to inhibition of arrhythmogenic factors, such as tachycardia, hypertension, increased activity of the sympathetic nervous system, reducing the rate of excitation of heart pacemakers. In contrast, non-selective beta-blockers, Bisogamma in medium therapeutic doses has no significant effect on other organs that contain beta-adrenergic receptors (bronchi, uterus, skeletal muscle, pancreas).

According to the instructions, Bisogamma poorly penetrates the blood-brain barrier. Also, the low permeability of the drug formulation through the placental barrier. The secretion of the drug in breast milk - is low.

Bisogamma maximum drug concentration in plasma was 1-3 hours after ingestion, it is displayed at 50% kidney unchanged, and 50% is metabolized in the liver. The half-life of 10-12 hours.


  • hypertonic disease;
  • Coronary artery disease with angina (to prevent attacks).

Contraindications Bisogamma

Contraindications: hypersensitivity to the components of the drug, as well as hypersensitivity to other beta-blockers.

According to the instructions, Bisogamma contraindicated in: shock, pulmonary edema, collapse, congestive heart failure, decompensated chronic heart failure, atrioventricular block 2-3 tbsp., Bradycardia, cardiomegaly, severe bronchial asthma and chronic obstructive pulmonary disease. Also, the drug should not be taken with pheochromocytoma, depression, Raynaud's disease, and at the age of 18 years (studies in this population have not been conducted).

In the opinion of Bisogamma should be used with caution in patients with chronic renal failure, liver failure, hyperthyroidism, diabetes mellitus, psoriasis.

Use during pregnancy and lactation

The drug Bisogamma possible during pregnancy if the potential benefits from taking it higher than the risk of side effects in the fetus.

Instructions Bisogamma: Dosage and administration

According to the instructions, Bisogamma taken once in the morning on an empty stomach. Reception starts with a dose of 5 mg, in case of need the dose may be increased to 10 mg. The maximum daily dose of 20 mg.

In patients with impaired renal function (or liver), the maximum daily dose of 10 mg.

side effect

Admission Bisogamma can cause adverse reactions in the nervous system in the form of fatigue, weakness, dizziness, sleep disorders, depression, tremors, convulsions .  On the part of the cardiovascular system may experience side effects such as bradycardia (slowing of heart rate less than 60 beats per minute), atrioventricular block, increased congestive heart failure, orthostatic hypotension, peripheral vasoconstriction (cold extremities, increasing incidence of Raynaud's syndrome) .  On the part of the gastrointestinal tract are possible: dry mucous membranes, nausea, violation of a chair, changes in taste .  The respiratory system, according to the instructions Bisogamma possible: difficulty breathing (when using high doses), bronchospasm (in predisposed patients to him), nasal congestion .  From the senses are possible side effects such as: blurred vision, dryness and soreness of eyes, conjunctivitis .  Also, allergic reactions such as hives, rash, pruritus .

From the laboratory parameters are possible: reduced number of platelets in the peripheral blood, agranulocytosis, leukopenia (reduction in white blood cells), elevated liver enzymes (ALT, AST).  Tablets Bisogamma 5 and 10 mg

According to reviews, Bisogamma rarely causes side effects and is well tolerated by patients.

Overdose Bisogamma

In case of overdose characterized by the following symptoms: premature beats, bradycardia, AV block, marked reduction in blood pressure, increase in symptoms of chronic heart failure, shortness of breath, dizziness, fainting, seizures, bronchospasm.

Treatment of overdose - washing stomach, absorbents, and symptomatic treatment.

Interaction with other drugs

Bisogamma alter the effectiveness of insulin and glycemic drugs, taken by mouth, may mask the symptoms of hypoglycemia.

The hypotensive effect of the drug is reduced NSAIDs, glucocorticoids and estrogens.

According to the instructions Bisogamma, its use in conjunction with cardiac glycosides, calcium channel blockers (verapamil, diltiazem), antiarrhythmic drugs increases the risk of bradycardia, AV block.

We do not recommend the use of Bisogamma together with MAO inhibitors.

According to reviews, Bisogamma with antidepressants and antipsychotic drugs may enhance the central nervous system depression.

Specific instructions for use of the drug Bisogamma

In the case of use of this drug is necessary to control the blood pressure and heart rate (HR) - at first every day, then 1 every 4-5 weeks. When the heart rate less than 50 beats per minute should immediately consult a doctor. It is also necessary to monitor the ECG and patients with diabetes control blood sugar. Smokers efficiency Bisogamma below. When lung disease before taking the medication recommended by the study of respiratory function.