Biprol - a drug used in the treatment of angina pectoris
 Biprol - the medicament from the group of beta-blockers (selective) which is used in the treatment of hypertension and angina. International name of the drug - bisoprolol.

Structure and Composition

Biprol available in tablet form at 5 and 10 mg.

The active substance - bisoprolol fumarate.

Pharmacological action Biprola

This drug has hypotensive (lowers blood pressure), antianginal and antiarrhythmic action. The hypotensive effect is associated with a decrease in cardiac output and peripheral vascular stimulation of the sympathetic nervous system. After receiving the drug antihypertensive effect occurs after 2-5 days. Stable effect of the treatment is expected in 1-2 months.

The maximum concentration according to the instructions Biprola observed after 1-3 hours after administration. The drug is metabolized in the liver and 50% is excreted by the kidneys unchanged and 2% is excreted in the bile.


  • Hypertonic disease;
  • Secondary hypertension;
  • Coronary heart disease (CHD) and angina.

Contraindications Biprola

Hypersensitivity to the ingredients, hypersensitivity to other drugs of the same group. According to the instructions Biprol can not be used in shock, pulmonary edema, congestive heart failure 4 f.kl., AV block grade 2-3, acute heart failure, hypotension (especially due to acute myocardial infarction), bronchial asthma and other obstructive lung diseases. Contraindications simultaneous reception Biprola or analogs with MAO inhibitors. Not Recommended intake dennogo means patients with pheochromocytoma, and metabolic acidosis.

According to the instructions Biprol should be used with caution in hepatic failure, chronic renal failure, myasthenia gravis, diabetes, hyperthyroidism, depression, psoriasis, AV block 1 tbsp. Using Biprola and analogs in pregnant women is possible only when the benefits of the use of the drug justifies the risk of side effects in the fetus.

Dosing and Administration

According to the instructions Biprol administered once a day for 5 mg. The drug is taken in the morning on an empty stomach. If necessary, the daily dose may be increased to 10 mg. The maximum possible daily dose - 20 mg.

Side effects Biprola

According to reviews Biprol rarely causes serious side effects .  From the nervous system may develop fatigue, weakness, dizziness, sleep disorders, anxiety, depression, asthenia .  Cardio-vascular system may occur: bradycardia, conduction disturbances infarction, AV block, arrhythmias, increasing incidence of cardiovascular disease, orthostatic hypotension, the occurrence of vasospasm (the peripheral blood circulation, cold extremities, worsening of the symptoms of Raynaud's disease) .  From the senses may have blurred vision, dry eyes, conjunctivitis .  On the part of the digestive tract may experience the following symptoms: nausea, vomiting, abdominal pain, stool disorders, changes in taste, hepatic dysfunction (cholestasis) .  The respiratory system can be marked difficulty in breathing (using high-dose Biprola) in predisposed patients may bronchospasm .  On the drug is also possible allergic reactions (rash, hives, itching) .  In patients with diabetes mellitus who receive insulin hypoglycemia may occur (decrease in blood sugar) .


Overdose symptoms: fainting, convulsions, bradycardia (slowing of heart rate less than 50 beats per minute.), Premature beats, arrhythmia, severe hypotension, difficulty in breathing, bronchospasm.

Treatment of overdose consists in gastric lavage, the appointment of absorbent. In the case of AV block shown atropine intravenously. If hypotension shown intravenous plasma-solutions in case of failure are appointed dopamine, dobutamine, epinephrine. With the development of heart failure using cardiac glycosides, diuretics. In case of seizure must enter diazepam intravenously.

Interaction Biprola with other drugs

 Biprol tablets
 When intravenous iodine-containing X-ray contrast agents in patients receiving Biprola and analogues increased risk of anaphylactic reactions.

According to the instructions Biprol alters the action of insulin and hypoglycemic drugs tablets. The drug masks the symptoms of hypoglycemia (low blood sugar).

Nonsteroidal anti-inflammatory drugs, glucocorticoids and estrogens, while the use Biprolom Review weaken its hypotensive effect.

This drug with cardiac glycosides and calcium channel blockers (eg, verapamil) and other antiarrhythmics increase rice emergence bradycardia, heart failure, and AV block.

According to the instructions Biprol with nifedipine and diuretics can lead to a significant reduction in blood pressure.

The combination of this drug with antidepressants and antipsychotics increases central nervous system depression.


Patients who began receiving instruction on Biprola requires monitoring of blood pressure daily, also necessary to monitor the ECG. In patients with diabetes is recommended to determine the level of blood glucose (at least 1 time in 1-2 months.). In the event of bradycardia less than 50 beats per minute should immediately consult a doctor. Patients with lung disease before taking Biprola recommended study of external lung function.

In the opinion of Biprol not effective in 20% of patients with angina. The main reasons for this is expressed atherosclerosis of the coronary vessels.

In chronic smokers, the effect of taking the drug reduced.

According to the instructions Biprola if the patient uses contact lenses, you need to consider the fact of reducing the production of tear fluid.

With the development of depression in a patient during treatment with the drug should be discontinued Biprolom.

Analogs Biprola

Biprola analogues are Aritel, Binogamma, Bidop, Bisokard, bisoprolol, Concor, Corbis, Kordinorm, Coronal, Niperten, Biol.