Binafin tablets
 Binafin (international name Terbinafine) - a drug for the treatment of fungal infections.

Structure and Composition

According to the instructions Binafin available in tablets of 125 and 250 mg. The drug is also available in the form of a cream (1%) in the box on 10 and 15g.

Terbinafine hydrochloride tablets in addition contain further auxiliary substances (microcrystalline cellulose, starch, povidone, colloidal silicon dioxide, sodium lauryl sulfate, sodium methylparaben, magnesium stearate, talc, sodium starch glycolate).

Binafin cream (1%) - 1 g of cream 10 mg terbinafine and auxiliaries (ketosterilovy alcohol, white soft paraffin, liquid paraffin, methyl paraben, ketomakrogol isoprene myristate, sodium hydrogen phosphate, propylparaben, water).

Pharmacological action Binafina

The drug belongs to the antifungal agents, it has a broad spectrum of action. According to the instructions Binafin inhibits fungal cells in the intracellular sterol synthesis, which leads to their death. The drug is effective against many species of fungi which cause diseases of the skin, hair and nails. Binafin compatible with other drugs, as they do not affect their metabolism. In appointing the drug in tablets in the skin, hair and nails are Binafina fungicidal concentrations (ie, resulting in the death of fungi).

The drug may be taken without regard to food, its maximum concentration in plasma - 2 hours after ingestion. Binafin quickly penetrate the layers of skin, sebum, which leads to the creation of high concentrations of drug to the hair follicles, the hair, skin. The nail penetrates the plastic Binafin a few weeks after starting treatment.

The half-life of the drug - 17 hours. Do not produced any evidence of the existence of cumulative effect (that is, the accumulation in the body). Patients with kidney and liver clearance rate Binafina may be delayed.

When the cream is absorbed Binafin about 5% of the dose.


  • Treating fungal infections of the skin (tinea);
  • The treatment of fungal infections of the scalp;
  • The treatment of onychomycosis (fungal infection of the nail) caused by dermatophyte fungi;
  • Yeast infections of the skin caused by fungi of the genus Candida (generalized);
  • Cream Binafin can be used in the treatment of pityriasis versicolor (unlike pills).

Contraindications Binafinu

Contraindications: Hypersensitivity to the ingredients Binafina. Since no studies on the use of the drug in patients with impaired liver function, its use is not recommended in these patients.

precautionary measures

If the treatment of the patient Binafinom occur: persistent nausea, vomiting, loss of appetite, pain in the right upper quadrant, fatigue, dark urine, lightening the chair, it is necessary to hand over the biochemical analysis of blood for liver enzymes (ALT, AST) and cancel the treatment with this drug. The patient should be aware of the need to see a doctor when such symptoms.

In patients with impaired renal function (blood creatinine levels at more than 300 mmol / l) a dose reduction is recommended Binafina 50%.

Influence Binafina on ability to drive and use machines

no data.

Use during pregnancy and lactation

Clinical experience Binofina pregnant women is very limited. The appointment of the drug is possible only in cases where the potential risk to the fetus below the expected effect of therapy. Binofin excreted in breast milk, so while taking the drug inside should abandon breastfeeding.

Dosing and Administration Binafina

 Cream in tubes Binafin
 Children under 2 years of use of this drug is not recommended.

According to the instructions assigned Binafin tablets 1 time per day.

Single dose for children is appointed on the basis of body weight of the patient:

  • Children less than 20 kg - 62 mg of 5 (half tablets of 125 mg);
  • For children weighing 20 to 40 kg - 125 mg;
  • Children over 40 kg - 250 mg.

In the opinion of Binafin well tolerated in children if swallowed.

Adults Binafin assigned 250 mg once a day.

According to the instructions Binafina duration of therapy depends on the severity of disease: infections of the skin 2-6 weeks; during infection of hair and scalp - 4 weeks; fungal infections in the nail plate - from 2 to 12 weeks.

Dose adjustment Binafina in elderly patients is not required if they have no effects of liver and kidney failure.

Cream Binafin designate adults and children over 12 years old. Apply the cream to the affected skin (previously they should be cleaned and dried) and then rub it lightly. In the opinion of Binafin cream is easy to apply, does not stain clothes and has a neutral odor. If the cream is used at night, the place of application can be covered with a gauze bandage. It is recommended to use the cream 1-2 times a day. The duration of treatment cream on Binafin instructions - 1-2 weeks.

side effects

According to reviews Binafin tablets are well tolerated by patients. Side effects are rare and are mild. Most often there are symptoms of the gastrointestinal tract (1-10%) - loss of appetite, nausea, abdominal pain, diarrhea. Also, there are skin reactions - rash, hives. If cutaneous manifestations appeared, it requires removal of the drug.

Described isolated cases of serious complications such as Stevens-Johnson syndrome (toxic epidermal necrolysis). Rarely (0, 1-1%) there is a violation of taste sensations. At 0, 01 - 0, 1% of the cases there is the appearance of a violation of the liver (cholestasis, hepatic failure).

In the opinion of Binafina cream rarely causes adverse reactions, mainly they appear redness, itching or hives occurrence on the site of application.

Interaction Binafina with other drugs

Clinical studies have shown that "in vitro" the drug has an overwhelming effect on the drugs such as oral contraceptives, cyclic antidepressants, beta - blockers and selective MAO inhibitors.


In overdose Binafinom (5 g) may appear headache, dizziness, nausea, abdominal pain. In case of overdose treatment involves the use of enterosorbents (such as activated charcoal), gastric lavage and symptomatic therapy appointment.