Azafen - a drug which has sedative and calming effects.

Release form and composition

Azafen belongs to the tricyclic antidepressants. It has sedative properties.

It is produced in the form of tablets containing 25 mg of active substance - pipofezine dihydrochloride monohydrate present in the carrier matrix.


  • potato starch;
  • Colloidal silicon dioxide (Aerosil);
  • Microcrystalline cellulose;
  • Lactose monohydrate;
  • Povidone (polyvinylpyrrolidone, low molecular medical);
  • Magnesium stearate.


Efficiency pipofezine based on relieving the symptoms of depression, so the indications for use are azafen depression of various origin, including:

  • Endogenous;
  • Exogenous;
  • Alcohol;
  • Senile.

Furthermore, the drug is used to treat the following conditions:

  • Depression with chronic physical illness;
  • Anxiety-depressive syndromes;
  • Depressive phase in manic-depressive syndrome;
  • Asthenoneurotic syndromes.

In the first place after the start of treatment comes improved mood, followed by anxiety and confusion disappear.


According to the instructions Azafenu tablets are contraindicated in:

  • Hypersensitivity to pipofezine;
  • Renal insufficiency;
  • Hepatic Insufficiency;
  • Heart attack;
  • Condition after a stroke;
  • Congestive heart failure;
  • Diabetes;
  • Infectious diseases.

Use during pregnancy and lactation, and in parallel with the reception of MAO inhibitors. In children taking an antidepressant only on doctor and under close medical supervision. This is due to insufficient data on the safety of children Asaph.

Dosage and Administration

The tablets are taken orally, with a small amount of liquid. The initial dose is 25-50 mg per day for the two steps. If necessary, in the absence of negative effects may increase the dose up to 200 mg per day, to be taken two or three times. The maximum amount of the drug is 500 mg per day.

After stabilization of the recommended maintenance dose, which is about 25-75 mg per day. Duration of treatment - from one month to one year.

Azafen no negative effect on the heart. Completely and in a short period absorbed from the stomach and intestines.

side effects

The drug is very well tolerated and does not cause drowsiness and enhances the feeling of fear, though certain side effects may still be present.

According to the instructions Azafenu, it could cause headaches, allergic reactions, vomiting or nausea, dizziness. In these cases it is recommended dose reduction.


During the period of drug administration is forbidden alcohol.

From time to time it is necessary to monitor the functioning of the liver and kidneys.

During treatment, patients must Azafenom refrain from activities that require increased attention and rapid psychomotor reactions, for example, the vehicle control.


Pipofezine not included in other preparations.

Analogues azafen mechanism of action are:

  • Alventa;
  • Befol;
  • Velaksin;
  • Deprez;
  • Coaxil;
  • Mirtazonal;
  • Normazidol;
  • Pirazidol;
  • Tetrindol;
  • Esprital and other drugs.

Terms and conditions of storage

Store in a dry, dark place at a temperature not exceeding 25 ° C. Shelf life - 3 years.