Atorvastatin is a lipid-lowering drug of the statin, designed to lower blood cholesterol levels.

Structure and Composition

 Atorvastatin is a lipid-lowering drug of the statin
 The preparation contains 10 mg of atorvastatin calcium salt and auxiliary components (cellulose, corn starch and talc). Atorvastatin produced in the form of tablets of 10-80 mg, placed in a cardboard box for 10-30 pieces.

The pharmacological properties of atorvastatin

Atorvastatin is a drug directional, reduces cholesterol in the blood. The mechanism of action is to regulate the speed of change of HMG to mevalonate.

Patients with elevated cholesterol hereditary and non-hereditary nature after taking this drug can reduce the content density lipoprotein, as well as reduce levels of triglycerides.

Good reviews of atorvastatin obtained as a medicine, reducing cholesterol and increasing the synthesis of receptors on the surface of liver cells. After the course, atorvastatin reduced the risk of developing coronary heart disease and myocardial infarction. This preparation improves the cardiovascular system as well as a preventive agent for cardiovascular disease and stroke. Atorvastatin absorption in the digestive organs is achieved within 2 hours and the bioavailability is 12-15%. The drug is metabolized in the liver, forming a plurality of active components and inactive metabolites. Atorvastatin is eliminated from the body within 15-20 hours from the urine and feces.

Patients with disorders of the liver may be an increase plasma concentrations of atorvastatin.

Indications atorvastatin

Atorvastatin is administered as part of combination therapy to reduce the level of total cholesterol, LDL and triglycerides.

Positive feedback received atorvastatin as a drug, increases high-density lipoprotein. Atorvastatin also used to improve the function of the cardiovascular system and the prevention of hypertension, diabetes, myocardial infarction, coronary heart disease, angina and stroke.

A lot of positive feedback has both atorvastatin medicines for children, aimed to reduce total cholesterol and improve cardiovascular system in the postoperative period.

Analogs of atorvastatin

Analogues of atorvastatin are Atokord, Atomaks, Atoris, Vazator, lipon, Torvakard and Tulip. These drugs have similar pharmacological actions and are intended to reduce the level of cholesterol in the blood.

Atokord and Torvakard as atorvastatin analogues are effective for the treatment of hypercholesterolemia, a hereditary type.

Instructions for use of atorvastatin

In accordance with the instruction of atorvastatin should be taken orally one time a day, regardless of the meal, but with plenty of water.

Before the appointment of treatment the doctor must carry out therapeutic measures aimed at reducing body weight, including diet and assigned a set of daily exercise. Atorvastatin can be administered on a background of compliance with anti-cholesterol diet. Duration of treatment is determined by a physician in accordance with the diagnostic indications of the patient.

According to the instructions of atorvastatin for hyperlipidemia and hypercholesterolemia, mixed type should take 10 mg a day. When hereditary hypercholesterolemia type appoint 50-70 mg 1 time a day.

Children from 12 to 16 years old can receive atorvastatin 10 mg 1 time a day. If necessary, the dosage was increased to 1 20 mg once a day. Instructions prescribe atorvastatin sure to adjust the dosage in elderly patients with severely impaired renal function.

The maximum daily dose of the drug for adults should not exceed 80 mg, and for children - 40 mg. Before the course of treatment should be to check the functioning of the liver, kidneys and digestive system.


 Atorvastatin is produced in the form of tablets 10-80 mg
 Atorvastatin is contraindicated in the presence of hypersensitivity and allergic reactions to its components, severe liver disease and kidney failure, pregnancy and lactation, in children under 12 years.

The drug is given to patients is unacceptable to the individual syndrome, lactose intolerance and galactosemia.

With careful preparation is prescribed in alcoholism, severe diseases of the digestive system, endocrine disorders, hypotension, infectious diseases, epilepsy, trauma and after a hemorrhagic stroke.

Side effects of atorvastatin

Atorvastatin can cause a number of side effects. These include:

  • On the part of the central nervous system - headache, dizziness, loss of coordination, fatigue, neuropathy, cramps, hallucinations;
  • From the digestive system - decreased appetite, sudden weight loss, diarrhea, vomiting, nausea, flatulence, dyspepsia, pancreatitis, constipation, colitis, gastritis, peptic ulcer disease, cholestasis, hepatitis;
  • On the part of the musculoskeletal system - myositis, muscle cramps and spasms, pain in the joints;
  • From the circulatory system - circulatory disorders, thrombocytopenia.

Atorvastatin can cause allergic reactions, including itching, hives, dermatitis, bronchospasm, alopecia. This drug in high doses increases the risk of fungal diseases, myalgia, memory disorders, and fatigue.