Antistius - Antihypoxanth medication used in the treatment of heart disease.
Pharmacological action Antistius
The main active ingredient tablets Antistius - trimetazidine dihydrochloride, directly affects the neurons and cardiomyocytes of the brain that allows you to optimize their function and metabolism. Also, the drug has a cytoprotective effect, which is caused by the activation of oxidative decarboxylation, increased energy capacity and rationalization of consumption of oxygen.
Application Antistius helps prevent depletion of intracellular adenosine triphosphate and phosphocreatine, and to maintain myocardial contractility in acidosis conditions, prevents the accumulation of calcium and sodium in cardiomyocytes and affect the normalization of the intracellular concentration of potassium.
Also, the use Antistius reduces the concentration of phosphate and intracellular acidosis due to reperfusion and myocardial ischemia increases the electrical potential, the ability to prevent free radicals have a damaging effect, preserves the integrity of cell membranes and prevents the activation of neutrophils in the ischemic area, reduces the yield of creatine kinase from the cells and the severity of ischemic damage infarction.
According to the instructions Antistius used in angina pectoris, reduce the frequency of attacks, and after two weeks of treatment improves exercise tolerance and reduces the blood pressure drops. When vascular pathology eyes able to restore functional activity of the retina.
According to the instructions Antistius manufactured as coated tablets with 20mg of polymer packaging container. One tablet of the preparation contains 20 mg of trimetazidine dihydrochloride.
Antistius analogues of the active substance are:
- Angiozyme retard;
- Vero Trimetazidine;
- Deprenorm MW;
- Trimitard MW;
By analogues Antistius mechanism of action and of belonging to a group of pharmacological drugs include:
- Hawthorn flowers raw vegetable;
- Doppelgerts Kardiovital;
- Ezafosfina lyophilisate;
- Sodium triphosphate;
- Neoton lyophilisate;
Antistius administered in combination therapy in the prevention of coronary heart disease, vertigo of vascular origin, chorioretinal vascular disorders, as well as ischemic disorders cochleovestibular nature.
In accordance with the instructions Antistius taken orally during meals two or three 40 or 60 mg tablets twice or thrice a day. The course of treatment is determined by the attending physician.
In accordance with the instructions Antistius contraindicated in case of hypersensitivity to the drug, renal insufficiency, severe hepatic impairment, pregnancy and lactation and children under the age of 18 years.
Application Review Antistius causes complications from the various systems of the body, namely:
- Nausea, diarrhea, vomiting, abdominal pain and dyspepsia (digestive system);
- Tides in the face and orthostatic hypotension (cardiovascular system);
- Tremor, headache, stiffness, dizziness and akinesia (central nervous system).
Also, reviews Antistius may cause asthenia, rash, urticaria, and pruritus.
In accordance with the instructions Antistius must be stored out of reach of children and protected from light, dry place at room temperature to 25 ° C. Shelf life of the drug in compliance with the recommendations of 3 years, after which the application Antistius unsafe.