Ambroxol is a mucolytic agent that is a drug that thins the mucus and facilitates its removal from the lungs. The active ingredient of the drug is ambroxol hydrochloride. The main action Ambroxol directed to increased secretion of glands airway stimulation activity villi airways, increased separation process surfactant (surfactant) light. All these processes lead to the fact that the discharge of mucus and facilitates the process of its removal, which in turn reduces the cough. Application Amroksola reduces bronchial hyperreactivity and causes excess secretion of Education. Ambroxol is a metabolite of bromhexine hydrochloride, differing from it in its non-toxic and more effective.
After applying Ambroxol starts to operate after 30 minutes, while maintaining its therapeutic effect for 9-10 hours. Absorption (suction) of the drug occurs rapidly and almost completely. Reaching the maximal plasma levels can be observed at 0, 5-3 hours after administration. The binding to plasma proteins Ambroxol -within 80-90%. The drug is rapidly distributed into the tissues from the blood, especially in the lungs. Ambroxol is metabolized in the liver and excreted by the kidneys (90% - water-soluble metabolites, 5% - unchanged).
This drug is given in the following diseases:
- chronic obstructive pulmonary disease;
- chronic and acute bronchitis, tracheobronchitis;
- cystic fibrosis;
- bronchial asthma with difficult expectoration.
Ambroxol for children is one of the most popular mucolytics.
Ambroxol is available in the form of sustained-release capsules, oral solution, syrup Ambroxol, a solution for intravenous administration Ambroxol tablets and solution for oral and inhalation. Ambroxol tablets may be conventional, long-acting, or fizzy.
Ambroxol syrup may have a concentration of 15 mg per 5 ml or 30 mg per 5 ml, depending on what is calculated and the dosage of the drug. Syrup Ambroxol taken at the rate of 30 mg at a time (adults and children over 12 years of age) and 15 mg at a time (for children up to 12 years). Take the drug in this form should be three times a day.
Ambroxol tablets administered orally with meals and drink small amounts of water. Ambroxol One tablet contains 30 mg of active substance. If the drug is taken three times a day, while the dose regimen for adults and children over 12 years is as follows: po30 mg the first 2-3 days, followed by a move to ½ tablet or continue to take one tablet, then the multiplicity of methods should be reduced to two times a day . Ambroxol for children under 12 years: ½ tablet, the number of methods in its sole discretion determines the physician - two or three times.
According to the instructions, in the form of Abroksol oral solution (7, 5 mg / ml) three times per day for adults is assigned as follows: 4 ml of the first two or three days, followed by a single dose should be reduced to 2 ml, You can reduce the number of receptions to two a day and left the previous dose (4 ml). Ambroxol for children 5-12 years old is assigned to 2 ml, the multiplicity of reception - two or three times a day; children 2-5 years - 1 ml of the drug should be taken three times a day; relative to children under 2 years job recommended dose is 1 ml to be taken twice a day.
Without medical supervision Ambroxol should not be used longer than five days.
This drug is well tolerated, side effects are very rare.
The instructions for use contain the following Amroksola negative consequences of his admission:
- heartburn, dry mouth, dyspepsia, vomiting, nausea, diarrhea;
- rash, urticaria, anaphylactic reactions, angioedema, allergic reactions;
- weakness, headache;
- very rarely - Stevens-Johnson syndrome, Lyell's syndrome.
Ambroxol is not assigned if the patient has:
- hypersensitivity to the drug;
- Hereditary disorders of carbohydrate tolerance (product contains lactose);
- duodenal ulcer;
Use of Ambroxol is contraindicated during the first trimester of pregnancy.
Apply Ambroksol convenient for children as a syrup. This form of release of the drug can be administered to patients with diabetes. Patients suffering from bronchial asthma, bronchodilators should be taken prior to the inhalation of ambroxol.
Store medication at room temperature in a dry and dark place. Shelf life is 3 years Ambroxol.