Ambisome - an antibiotic antifungal action.

Release form and composition

Ambisome produced in powder form and a solution for infusion.

The active ingredient of the drug - liposomal amphotericin B.


According to the instructions, Ambisome prescribed for:

  • Cryptococcal meningitis;
  • Disseminated cryptococcosis;
  • Disseminated forms of candidiasis;
  • North American blastomycosis;
  • Phycomycosis;
  • Histoplasmosis;
  • Chronic mycetomas;
  • Coccidioidomycosis;
  • Gialogifomikoze;
  • American visceral and cutaneous visceral leishmaniasis;
  • Systemic fungal infections, showed on the background of AIDS;
  • Immunodeficiency which has arisen during the anticancer therapy.

Application Ambizoma also shown in patients with oncopathology complicated by neutropenia - to prevent the development of fungal infections, and patients receiving bone marrow transplant or parenchymal organs.

In accordance with the instructions Ambisome effective at a feverish syndrome of unknown origin, after continuing for 4 days of antibiotic therapy, the problems of patients who are prone to fungal infections or patients with neutropenia.


Do not use this Ambizoma concurrently with the infusion of leukocyte mass, as well as in case of hypersensitivity to the active substance means.

Ambisome in combination with drugs that suppress the growth of tumors can cause a decrease in pressure, bronchospasm, and renal dysfunction.

Dosage and Administration

According to the instructions Ambisome administered intravenously over 30-60 minutes. For the treatment of systemic mycosis administered 1 mg / kg / day, increasing the dosage if necessary to 3 mg / kg / day.

The treatment lasts 2-4 weeks, during which time you must enter the 1-3 g of the drug.

To prevent invasive fungal infections arising during transplantation of parenchymal organs administered 1 mg / kg / day of agent over 5 days after surgery.

Patients with HIV infection complicated with disseminated cryptococcosis, take the 3 mg / kg / day for 6 weeks. After that, in some cases, to prevent recurrence of infection, appoint another 1 course of treatment.

For the treatment of visceral leishmaniasis for 21 days take 1-1 5 mg / kg / day or 3 mg / kg / day Ambizoma for 10 days. The same dosage used in immunodeficiency.

Patients with neutropenia formed after undergoing chemotherapy or application of high doses of glucocorticosteroids have to take 2 mg / kg / day. To eliminate fever refractory to antibiotic therapy, Ambisome administered in a dosage of 1-3 mg / kg until normal temperature and neutrophils (1 thousand / ml).

Babies preparation can be administered in the same dosages, calculated on the basis of body weight.

Before applying Ambisome was dissolved in sterile water, which does not contain bacteriostatic additives, to achieve a concentration of 4 mg / ml. Thus, one vial of 50 mg of the drug accounts for 12 ml of water. After adding the liquid bottle is shaken until a homogeneous suspension.

side effects

Application Ambizoma may cause the following side effects:

  • Nausea;
  • Vomiting;
  • Increased activity of liver enzymes;
  • Azotemia;
  • Tubular renal acidosis;
  • Chills;
  • A rash on the skin;
  • Trouble breathing;
  • Fever;
  • Chest pain and lower back;
  • Anaphylaxis;
  • Hypokalemia;
  • Hemolysis;
  • Headache;
  • Yellowing of the skin and sclera.

In addition, at the injection site may develop thrombosis or phlebitis.


Hypokalemia, and pathology of the cardiovascular system is the simultaneous reception of the drug with corticosteroids, adrenocorticotropic hormone, carbonic anhydrase inhibitors.

Combining Ambizoma with haematological drugs cause bone marrow suppression.

In turn, the agent may enhance the toxicity of cardiac glycosides, flucytosine, nephrotoxic drugs, muscle relaxants.

Not combined preparation with salt solutions (including saline).

Solvents containing bacteriostatic additives can lead to precipitation.

Imidazole antifungal drugs cause resistance to amphotericin B.


Ambizoma analogues are:

  • Amfoglyukomin in pill form;
  • Amphotericin B and Amfotsil - in the form of freeze-dried;
  • Ampholip as a concentrate for solution for infusion.

Terms and conditions of storage

Ambisome should be stored in a dry place, away from children, at temperatures up to 25 ° C. Means in diluted form can be stored only hours, observing a certain temperature - 2-8 ° C.

Shelf life is 3 years.