Denebola gel
 Denebola - a non-steroidal anti-inflammatory agent used in diseases of the musculoskeletal system, connective tissue disorders, pain syndromes of different genesis, inflammatory processes.

Pharmacological action

Denebola has anti-inflammatory, analgesic, antipyretic and anti-edema properties.

Denebola has the ability to inhibit the release of mediators of inflammation, pain, fever, appearance of pro-inflammatory factors.

Denebola gel, in addition to rofecoxib, contains active ingredients such as linseed oil (softening effect), methyl salicylate (analgesic and anti-inflammatory effect), menthol (gives a feeling of cold and curative effect for the skin), fenoksienatol.


Apply Denebola guide recommends that you:

  • rheumatoid arthritis (a disease of the connective tissue with the defeat of small joints);
  • osteoarthritis (cartilage damage of the joints);
  • periarthritis (inflammation of periarticular tissues);
  • tendinitis (inflammation of the tendon tissue);
  • bursitis (inflammation of periarticular bags);
  • thrombophlebitis (blood clots and inflammation of the vein wall);
  • soft tissue injuries and musculoskeletal system;
  • pain syndromes of different origin;
  • stomatitis (lesion of the oral mucosa), pulp (pulp inflammation - the neurovascular bundle teeth), gingivitis (gum inflammation);
  • diseases of upper respiratory tract (sinusitis, otitis, laryngitis);
  • inflammation of the urinary and reproductive systems;
  • diseases of the upper respiratory tract;
  • eye diseases.

Instructions for use Denebola

Denebola is available in the form of tablets, injection, gel and rectal suppositories.

Denebola tablets are intended for use inside, taking them from the moment food intake does not depend. One tablet formulation may comprise 25 mg or 50 mg of rofecoxib. Denebola is recommended to take a tablet once a day. For the symptomatic treatment of primary dysmenorrhea, diseases of the genitourinary system, upper respiratory tract, pain relief is usually taken 25 mg of the drug, for further treatment - 12, 5-25 mg. The maximum daily dose should not exceed 25 mg rofecoxib. Initial dose Denebola rheumatoid arthritis and osteoarthritis is 12, 5 mg, taken once a day. Denebola pill should not take longer than 4-6 weeks.

 Denebola ampoule
 Denebola vial are intended only for intramuscular administration. Use this form of the drug can be no more than 1 time per day. At the initial stage of the treatment of pain and inflammatory processes content recommended Denebola ampoules of 2 ml (50 mg) was further possible to reduce the dose to 1 ml. In osteoarthritis the recommended initial dose - 12, 5 mg, in extreme cases - 25 mg. Denebola vials usually used at the beginning of treatment (approximately 1 week), then move to the use of tablets or gel.

Denebola gel is recommended 3-4 times a day, rubbing lightly into the skin. Denebola gel should be used in a small amount, commensurate adequate dose and the area of ​​the treated area. Avoid getting Denebola gel on mucous membranes, eyes and hands after use of the drug should be washed thoroughly. The course of treatment depend on the disease and the achieved effect.

According to the instructions, in the form of a suppository Denebola applied rectally, two times a day to 25 mg (1 candle). In osteoarthritis should enter into the anus one candle every night. Duration of treatment - 4-6 weeks.

Side effects

Adverse effects of the drug Denebola instructions are as follows:

  • drowsiness, dizziness, confusion, hallucinations;
  • blood disorders, hypertension, congestive heart failure;
  • diarrhea, heartburn, nausea, vomiting, pain and discomfort in the epigastric region (upper third of the stomach), aphthous stomatitis, dyspepsia;
  • renal insufficiency, decreased renal function;
  • rash, itching, hives, angioedema.


Not assigned Denebola, instruction confirms patients with asthma, cancer, disorders of the cardiovascular system (progressive atherosclerosis, stroke, myocardial infarction).

Denebola is contraindicated for children under 12 years of age, elderly persons (over 65 years), pregnant and lactating women.

If you are sensitive to or intolerant of rofecoxib other nonsteroidal anti-inflammatory drugs Denebola not assigned.

Additional Information

Denebola should be stored in a dark place at a temperature of air, corresponding to 15-25 0 C. Shelf life - 2 years.