Gonal F

 Gonal F - a drug that stimulates the growth and development of follicles
 Gonal F - human follicle stimulating hormone (follitropin alfa, FSH).


The drug belongs to a group of pituitary hormones, hypothalamic gonadotropin and their antagonists.

The composition of the drug and the release form

Available in the form of a solution for subcutaneous injection (colorless transparent solution) - Pen-filled syringe. A pen-syringe contains:

  • Active component - follitropin alfa 300 IU (or 22 micrograms), 450 IU (or 33 micrograms), 900 IU (66 micrograms or);
  • Auxiliary components: water for injection, sodium hydroxide, phosphoric acid, m-cresol, sodium dihydrogen phosphate monohydrate, poloxamer, sucrose, sodium hydrogen phosphate dihydrate, methionine.

Pharmacodynamics preparation Gonal F

The drug is a recombinant human FSH stimulates the growth and development of follicles. Get FSH by genetic engineering of a Chinese hamster ovary cells. It has gonadotropin action: promotes the growth and maturation of follicles develop several follicles in the case of controlled ovarian hyperstimulation during the program of assisted reproductive technology (ART).

The clinical study, as well as numerous positive reviews of Gonal F for the ART program and ovulation induction showed greater efficiency follitropin alfa compared with urinary FSH. Compared with urinary FSH it contributes to the process of maturing follicles, reduce the cumulative dose and duration of treatment, reducing the risk of unwanted ovarian hyperstimulation.

Thus, during the appointment ART Gonal F by treatment instructions will be shorter, and the number of oocytes retrieved - as compared with urinary FSH.

It is also proved that follitropin alpha promotes stimulation of steroidogenesis and follicular development in women with suppression of endogenous gonadotropins, despite the low level of LH, inaccessible to measurement.

Indications for use of the drug Gonal F

 Gonal F - solution for subcutaneous injection
 Gonal F according to the instructions prescribed for these indications in men:

  • Stimulation of spermatogenesis in the hypogonadotropic hypogonadism (in combination with hCG).

Gonal F for instructions for women is prescribed in such cases:

  • Controlled ovarian hyperstimulation during the ART program;
  • Ovarian stimulation with severe shortage of LH and FSH (in combination with drugs LH);
  • Anovulation (including polycystic ovarian while) in the case of failure of treatment with clomiphene.


Gonal F drug is contraindicated according to the instructions in the following cases:

  • Hypothalamic-pituitary tumors, hypersensitivity one or more components of the formulation;
  • During pregnancy;
  • Ovarian cysts or tumors volume (not caused by polycystic ovarian) cancer, breast cancer, ovarian cancer, uterine cancer, uterine bleeding of unknown etiology;
  • It should appoint Gonal F according to the instructions in cases where not received the expected effect: If uterine fibroids and anomalies of genital organs in women that are not compatible with pregnancy, premature menopause, primary ovarian failure. The men - in the case of primary testicular failure.

Use of the drug during pregnancy and lactation

It should not be prescribed the drug during pregnancy and lactation.

Possible side effects

Use in women:

  • central nervous system. When using Gonal F responses indicate a likelihood of headaches.
  • Respiratory. There were very few reviews of Gonal F on patients with bronchial asthma symptoms or the worsening of the disease exacerbation.
  • Gastrointestinal tract. Often there are abdominal pain, discomfort, heaviness, nausea, vomiting, diarrhea.
  • the immune system. There were very few reviews of Gonal F o of allergic reactions (rash, redness, hives, swelling of the face, shortness of breath). There were isolated cases of complex allergic reactions including anaphylactic shock.
  • Breast and reproductive system. Often there are ovarian cysts, ovarian hyperstimulation syndrome mild to moderate severity. Sometimes there is a severe form of ovarian hyperstimulation syndrome, is rare - complications OHSS, ectopic (mainly women with diseases of the fallopian tubes), or multiple pregnancy.
  • the cardiovascular system. Very rarely can develop thromboembolism associated with severe OHSS.
  • Local reactions. Very often, patients complain of occurrence of injection site reactions (redness, swelling, pain, bruising).

Application men:

  • Respiratory. There were very few reviews of Gonal F on patients with bronchial asthma symptoms or the worsening of the disease exacerbation.
  • the immune system. Very rarely you may experience allergic reactions (hives, facial swelling, rash, redness, difficulty breathing), as well as the emergence of severe allergic reactions, including anaphylactic shock.
  • Breast and reproductive system. Often there were reviews of Gonal F on the occurrence of varicocele patients and gynecomastia.
  • Local reactions. Patients often complain about the appearance of injection site reactions (pain, bruising, redness, swelling).
  • Skin and subcutaneous tissue. Men often appear acne.
  • Other side effects. Increased body weight.

In case of unknown side effects need to inform your doctor.

Interaction with other drugs

The combination preparation Gonal F with other stimulant drugs (clomiphene, hCG) enhances the response of the ovaries.

Increasing the dosage of the drug is needed against the backdrop of the desensitization of the pituitary GnRH agonist or antagonist (the response of the ovaries is reduced).

There are no reviews of Gonal F and its combination with other drugs have been reported.