acetylsalicylic acid

 acetylsalicylic acid
 Aspirin is a drug with a pronounced anti-inflammatory, antipyretic, analgesic, and antiplatelet (reduces the process of platelet aggregation) effects.

Pharmacological action

The mechanism of action of acetylsalicylic acid due to its ability to inhibit the synthesis of prostaglandins, which play a major role in the development of inflammation, fever and pain.

Reducing the number of prostaglandins in the center of thermoregulation leads to vasodilatation and an increase in sweating, which leads to the antipyretic effect of the drug. Furthermore, the use of aspirin to reduce the sensitivity of nerve endings to the mediators of pain by reducing the impact on them of prostaglandins. The ingestion maximum concentration of acetylsalicylic acid in the blood can be observed within 10-20 minutes, and formed by metabolism of salicylate - after 0, 3-2 hours. Displayed acetylsalicylic acid through the kidneys, the half-life - 20 minutes, the half-life for salicylate - 2 hours.

Indications for use of acetylsalicylic acid

Aspirin, indications for which are due to its properties, is indicated for:

  • acute rheumatic fever, pericarditis (inflammation of the serous membrane of the heart), rheumatoid arthritis (loss of connective tissue and small vessels), rheumatic chorea (involuntary muscle contractions seen), Dressler's syndrome (a combination of pericarditis is inflammation of the pleura, or pneumonia);
  • pain syndrome mild to moderate intensity: migraine, headache, toothache, menstrual pain, osteoarthritis, neuralgia, pain in joints and muscles;
  • diseases of the spine, accompanied by pain: sciatica, lumbago, low back pain;
  • feverish syndrome;
  • the need for the formation of tolerance to anti-inflammatory drugs in patients with "aspirin triad" (a set of asthma, nasal polyps and aspirin intolerance) or "aspirin" asthma;
  • prevention of myocardial infarction in coronary heart disease or relapse prevention;
  • risk factors for silent myocardial ischemia, coronary heart disease, unstable angina;
  • prevention of thromboembolism (blood clots), mitral valvular heart disease, prolapse (dysfunction) of the mitral valve, atrial fibrillation (loss of atrial muscle fibers ability to work in synchronization);
  • acute thrombophlebitis (inflammation of the vein wall and thrombus formation, closing it clearance), pulmonary infarction (blockage of a blood clot blood vessels that feed the lung), recurrent pulmonary embolism.

Instructions for use of acetylsalicylic acid

 Acetylsalicylic acid tablets are intended for oral administration, it is recommended to take after a meal, drinking milk, or a conventional alkaline mineral water.

Apply an adult aspirin instruction recommends 3-4 times a day 1-2 tablets (500-1000 mg), and the maximum daily dose - 6 tablets (3 g). The maximum duration of use of aspirin - 14 days.

In order to improve blood rheology, and as an inhibitor of platelet adhesion designate ½ acetylsalicylic acid tablets a day for several months. Myocardial infarction and secondary prevention of myocardial infarction guide to acetylsalicylic acid recommends taking 250 mg per day. Dynamic cerebrovascular accidents and cerebral thromboembolism suggest reception ½ tablets of acetylsalicylic acid gradually adjusting the dose to 2 tablets a day.

Aspirin children assigned to the following single doses: over 2 years - 100 mg, 3-year life - 150 mg, a four - 200 mg over 5 years - 250 mg. Taking aspirin is recommended for children 3-4 times a day.

side effects

Aspirin, the application must be approved by a doctor can cause side effects such as:

  • nausea, vomiting, anorexia, abdominal pain, diarrhea, abnormal liver function;
  • blurred vision, headache, aseptic meningitis, tinnitus, dizziness;
  • anemia, thrombocytopenia;
  • prolonged bleeding, hemorrhagic syndrome;
  • renal failure, nephrotic syndrome, acute renal failure;
  • bronchospasm, angioedema. skin rash, "aspirin triad";
  • Reye's syndrome, increased symptoms of heart failure, a chronic nature.

Contraindications to the use of acetylsalicylic acid

Aspirin, indications of which determines the physician is not indicated for:

  • gastrointestinal bleeding;
  • erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
  • "Aspirin triad";
  • reactions to the use of acetylsalicylic acid or other anti-inflammatory drugs in the form of rhinitis, urticaria;
  • hemorrhagic diathesis (diseases of the blood, which have a tendency to increased bleeding);
  • Hemophilia (slow blood clotting and increased bleeding);
  • gipoprotrombinemii (increased bleeding tendency due to the shortage of prothrombin in the blood);
  • dissecting aortic aneurysm (abnormal additional false lumen within the wall of the aorta);
  • portal hypertension;
  • deficiency of vitamin K;
  • kidney or liver failure;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • Reye syndrome (a serious liver and brain in children as a result of the treatment of viral infections aspirin).

Acetylsalicylic acid is contraindicated in children younger than 15 years old, nursing patients and pregnant women in the first and third trimester.

Even if the use of the drug suggested readings, acetylsalicylic acid is not appointed in case of hypersensitivity to it or other salicylates.

Additional Information

According to the instructions, acetylsalicylic acid should not be stored in a place where the temperature can rise above 25 0 C. In a dry place at room temperature, the drug will fit within 4 years.