The active substance ArifOn - indapamide

Arifon - a drug that has a diuretic, vasodilatory and hypotensive (reducing pressure) action.

The active substance ArifOn - indapamide.

Pharmacological action

The diuretic effect of the drug occurs in the kidney and is based on the mechanism of enhanced excretion of sodium and chloride ions, so that there is increased excretion of fluids.

Blood pressure lowering is achieved by relaxing vascular walls due to a change of movement of calcium through the cell membrane. This reduces the ability of blood vessels to contract. Due to the expansion of the vascular wall and decrease spasms is a decrease in blood pressure.

Application ArifOn not reduce or alter carbohydrate and fat metabolism in the body.

Arifon produced in the form of tablets retard. At the core of the tablet is a hydrophilic matrix through which the active substance is released slowly indalamid and helps to reduce the pressure on throughout the day.

Application ArifOn in a form of release allows you to assign a minimum dose, thereby reducing the risk of side effects. Purpose ArifOn retard dose more than 1, 5 mg per day leads to an increase diuretic effect and the side effects, with greater effectiveness in reducing pressure is not observed.

After oral administration, the drug is well absorbed from the stomach, the maximum dose of the drug in the blood is achieved in two hours after ingestion. A week after the beginning of treatment is observed Arifon constant drug concentration in blood. In indalamid 70% excreted in the urine, and 22% - in the faeces.

Indications ArifOn

Arifon retard is used for hypertension (high blood pressure).

Instructions for use and dose ArifOn

 Apply Arifon retard inside a pill is swallowed completely, without chewing and drinking water in large quantities.

According to the instructions for use ArifOn, an adult, he was appointed one tablet a day. It is advisable to take a pill in the morning. The maximum dose ArifOn retard per day is 1, 5 mg, which corresponds to a single tablet. Application ArifOn in increased dose brings enhanced hypotensive effect, but causes the risk of side effects.

The instructions for use ArifOn said that the treatment with this drug need to monitor the level of sodium, potassium, calcium and glucose in the blood serum.

Side effects ArifOn

In applying ArifOn retard the risk of adverse effects is lower than when taking other drugs based on indalamida.

Electrolyte Balance: may reduce the level of potassium or sodium in the blood, which leads to dehydration and can provoke orthostatic hypotension. Furthermore, there may be an increased content of uric acid, glucose and calcium.

Hematopoietic system: an overdose may develop diseases such as thrombocytopenia, leukopenia, agranulocytosis, various anemias, including aplastic and hemolytic.

Gastrointestinal tract: there may be vomiting, nausea, constipation, change in taste, dry mouth, pancreatitis. If disturbed the function of the liver, may cause hepatic encephalopathy.

Central nervous system: symptoms such as headache, fatigue, dizziness, paresthesia.

Allergic reactions: itching, maculopapular rash, exacerbation of systemic lupus erythematosus, urticaria.

Arifon retard should not be administered to people who have to deal with dangerous machinery or driving a vehicle. Application ArifOn athletes can provoke a positive reaction in doping control.


According to the instructions for use ArifOn, contraindications to the drug is a hypersensitivity of the organism to Arifon or sulfonamide derivatives, severe disorders of the kidneys and liver, hepatic encephalopathy, pregnancy and lactation, decreased potassium in the blood.

Because of the unproven safety ArifOn retard children and adolescents, this drug is not prescribed to these groups of patients.