Latin name - Pencrofton.

Penkrofton is antigestagens drug.

Composition Penkroftona

 Penkrofton prescribed for medical abortion
 The active substance - mifepristone.

One tablet of the preparation contains 200 milligrams Penkrofton mifepristone. As auxiliary substances are present lactose, microcrystalline cellulose, corn starch, calcium stearate and aerosil.

The tablets have a light yellow color with a greenish tint. Available marbling.

The pharmacological action of the drug Penkrofton

Penkrofton at blocks the activity of the progesterone receptor.


After one-time dosing Penkrofton of 600 milligrams of its maximum concentration in the body 1 is 98 milligrams per liter. This concentration is achieved through ninety minutes. The absolute bioavailability is 69%. Binding to plasma proteins is 98%, which is achieved through eighteen hours.

Indications of the drug Penkrofton

According to the instructions Penkrofton for medical termination of early pregnancy (up to 42 days of amenorrhea).

Contraindications Penkroftona

Contraindications Penkrofton are:

  • pregnancy, which exceeds the term of 42 days of amenorrhea;
  • Suspected ectopic pregnancy;
  • prolonged corticosteroid therapy;
  • Chronic adrenal insufficiency;
  • anemia;
  • anticoagulant treatment;
  • hemorrhagic disorders;
  • scarring of the uterus;
  • inflammatory diseases of the vagina;
  • Pregnancy, which appeared after the abolition of hormonal contraception, or from the use of intrauterine contraception;
  • Hypersensitivity to mifepristone;
  • smoking women who are over 35 years old;
  • uterine fibroids.

Dosing and Administration

The drug is indicated for Penkrofton ingestion of 600 mg (three 200 mg tablets) for a time under the supervision of a physician. After receiving the patient must be under medical supervision for at least two hours.

After a 8-14 days carried out a clinical examination by ultrasound. If there is no effect of drinking on the 14th day (ongoing pregnancy or incomplete abortion), the patient produces a vacuum aspiration. Further histological examination carried aspirate.

According to the instructions Penkrofton should be taken only under the supervision of highly qualified, trained and certified doctors, as well as with the necessary resuscitation equipment.

Side effects Penkroftona

During the procedure, excessive bleeding may occur, during which will have an immediate and surgery (curettage), and may also be painful sensations in the abdomen, inflammation of the uterus and appendages.

According to the instructions Penkrofton can cause discomfort in the abdomen, headache, weak condition, nausea and vomiting, dizziness, diarrhea, pyrexia.

Use during pregnancy and lactation

If you want to apply the drug Penkrofton in lactation period, you need to stop breast-feeding for two weeks after receiving Penkroftona.

precautionary measures

According to the instructions Penkrofton should not be administered to patients with hepatic or renal insufficiency. It should also be careful to use the drug in patients with bronchial asthma, cardiovascular disease and COPD.

Overdose Penkroftonom

 Penkrofton should be used only under medical supervision
 In case of overdose Penkrofton can trigger the development of adrenal insufficiency acute.

Interaction with other drugs Penkroftona

Penkrofton drug should not be administered with NSAIDs (including acetylsalicylic acid), as they may affect the efficiency Penkroftona.

Reviews Penkroftone

Reviews Penkroftone talk about its high efficiency in abortion. But this should be done only in designated areas under the strict supervision of a physician.