Mikrazim - enzyme preparation used as a replacement therapy for exocrine pancreatic insufficiency and to improve digestion.

Pharmacological action

The active substance Mikrazima - enzyme preparation of animal origin, which provides the digestion of proteins, fats and carbohydrates.

The drug, bypassing the stomach and duodenum, exerts its effect in the small intestine, where food digestion occurs, providing agitation of digestive enzymes with intestinal contents. In the opinion of Mikrazim it has the greatest effect after half an hour after ingestion.

Product form

Mikrazim discharged as clear gelatin capsules comprising the active substance in the form of brown microgranules with a characteristic odor. The capsules contain 10 000 IU (Mikrazim 10000) and 25 000 units of pancreatin. On 10-50 pieces in blister packs, plastic bottles or jars dark.

Indications Mikrazima

Mikrazim of instructions is used as replacement therapy in exocrine pancreatic insufficiency at:

  • Cystic fibrosis;
  • Chronic pancreatitis;
  • Surgery on the pancreas;
  • Tumors of the pancreas.

At the same time replacement therapy should be combined with the basic treatment of the disease.

As symptomatic therapy Mikrazim used in treatment for the correction of violations of the digestive process, which arose:

  • In diseases that are accompanied by violation of biliary excretion - cholecystitis, cystic growths, liver diseases, chronic diseases of the biliary tract, gall bladder stones;
  • After resection of the gall bladder, stomach and intestinal tract.

Mikrazim used to improve digestion at:

  • Errors in the diet, including the excessive use of fatty foods and irregular meals;
  • Sedentary lifestyle;
  • Abuse chewing function;
  • Prolonged immobilization.


According to the instructions Mikrazim contraindicated to apply at:

  • Exacerbation of chronic pancreatitis;
  • Acute pancreatitis;
  • Hypersensitivity to the Mikrazima.

Apply Mikrazim during pregnancy and lactation may be strictly on the grounds and under medical supervision.

Instructions for use Mikrazima

The dose is prescribed according to the instructions Mikrazima individually, based on diet and disease severity. Typically, the capsules taken with food. If the received dose of more than one capsule, then half the dose should be taken before meals, and the rest of it - during a meal. In case of difficulty swallowing capsules Mikrazima, their content can be added to a liquid diet immediately before intake.

In cystic fibrosis starting dose for children, taken with each meal, are calculated individually based in  Mikrazim 1000
 ECA, the severity of the disease, the severity of steatorrhea and nutritional status and age:

  • Children 1-4 years - 1000 U Mikrazima per 1 kg of body weight;
  • Older children - 500 IU Mikrazima per 1 kg of body weight.

Adult Mikrazima maintenance dose should not exceed 10000 units per 1 kg of body weight per day.

When replacement therapy in patients with chronic pancreatitis, or other types of exocrine pancreatic insufficiency, received doses of enzymes depend on the individual patient's dietary habits and degree of exocrine insufficiency.

If the presence of steatorrhea and diarrhea due to lower body weight, administered to 25 000 units of lipase with each meal. With good endurance Mikrazima dose can be increased up to 30 000-35 000 units on 1 reception. Where steatorrhea not as pronounced in the absence of diarrhea, usually take 1 capsule Mikrazima 10000 on food intake.

During ongoing enzyme therapy to prevent the development of constipation should eat plenty of fluids.

With an overdose of the drug may develop hyperuricosuria or hyperuricemia, children often Mikrazim in overdose causes constipation.

side effects

In the opinion of Mikrazim in high doses can cause digestive disorders, manifested as nausea, constipation or diarrhea, as well as hyperuricosuria and hyperuricemia.

Much less Mikrazim cause various allergic reactions.

The lowest manifestation of the side effects seen with the use of the capsule 1 Mikrazima 10,000 with every meal.

Enzyme therapy for Mikrazimom reviews may not be effective in worm infestations, dysbiosis, duodenostasis or non-recommended regimen.

In an application Mikrazima with iron preparations may decrease iron absorption.

storage conditions

The drug is sold without a doctor's prescription, Mikrazima shelf life - 2 years.