Adalat has a pronounced hypotensive, vasodilatory and anti-anginal effect. It causes a decrease in peripheral vascular resistance and the expansion of the coronary arteries.
Release form and composition
Active substance Adalat - nifedipine, reducing movement of calcium ions through calcium channels inside cells.
The drug is available as a solution for infusion and tablets.
In a cardboard box along with a vial containing a solution, placed a special disposable syringe and connecting tube for infusion, the use of which reduces the loss of nifedipine when administered.
One vial contains 5 mg Adalat active substance in 50 ml of infusion solution.
- Ethanol 96% - 7, 500 g;
- Macrogol 400 - 7 500 g;
- Sodium hydroxide 0 1 N - pH 4, 5-7, 5;
- Water for Injection - 34, 995
One tablet Osmo-Adalat coated liner consists of nifedipine 30 mg or 60 mg.
- Magnesium stearate;
- Polyethylene oxide;
- sodium chloride;
- Iron oxide red;
- Cellulose acetate;
- Polyethylene glycol-4000;
- Opadry OY-S-24914 (iron oxide red + titanium dioxide).
The instructions to the Adalat contain the following diseases for which it is advisable to use it:
- hypertensive crisis;
- arterial hypertension;
- cardiac ischemia;
- Prinzmetal angina.
Treatment Adalat impossible in some cases. It:
- Unstable angina;
- Cardiogenic shock;
- The first four weeks after acute myocardial infarction;
- Age of 18 years;
- Pregnancy and breast-feeding;
- Hypersensitivity to nifedipine.
Use of the drug is contraindicated with concurrent use of rifampicin. Caution is required in the treatment of certain diseases that are specified in the instruction to Adalat:
- Subaortalny or severe aortic stenosis;
- Congestive heart failure;
- Cerebrovascular accidents severe;
- Liver failure;
- Severe hypotension.
The old age of the patient is also a condition of careful use of Adalat.
Dosage and Administration
Adalat be administered intravenously over 4-8 hours, and the rate of administration should not exceed 125 ml / h (1, 25 mg of nifedipine / h).
Maximum Daily Dose should correspond 15-30 mg of active substance.
Infusion therapy can be carried out for 3 days, then the patient should be transferred to oral.
The tablets are taken orally, 30 mg 1 time a day.
The most frequently occurring adverse effects include:
- Flushing, causing a sensation of heat, lowering blood pressure, tachycardia;
Less common (incidence of less than 1%) after application of Adalat can occur following unintended consequences:
- The worsening symptoms of heart failure, chest pain;
- A rash on the skin, burning and pain at the injection site;
- Nervousness, dizziness;
- Increased sweating.
Adalat contains an amount of ethanol corresponding to 45 g of ethanol per daily dose. This should be taken into account when appointing nifedipine patients suffering from alcoholism or impaired alcohol metabolism, pregnant and lactating women, children and patients with liver disease or epilepsy.
Ethanol can affect the action of other drugs disrupt the ability to drive vehicles and to work with require attention mechanisms.
Nifedipine is an active substance of the following drugs:
Analogues Adalat mechanism of action are:
- Felodipine and a number of other drugs.
Terms and conditions of storage
Store in a dark place at a temperature not exceeding 25 ° C.
Shelf life is 2 years and is specified on the package.
Adalat is sold in pharmacies by prescription.