Coronal - beta-blockers, used to treat heart and vascular disease.
Coronal peculiar antihypertensive, antianginal, antiarrhythmic effect.
In small doses Coronal blocks cardiac beta-blockers, reduces intracellular calcium current, depresses conduction, excitability, reduces heart rate, miokardnuyu contractility.
Total peripheral vascular resistance increased in the first days after the application of Coronal, later 2-3sut. it reaches the baseline and decreases during prolonged therapy.
Coronal hypotensive effect due to the fact that the drug reduces minute volume of blood, inhibits the activity of the renin-angiotensin system, restores normal sensitivity located in the aortic arch baroreceptors, affects the nervous central system. Reduced pressure in patients with arterial hypertension occurs through 2-5sut. Coronal after initiation of therapy. Sustained antihypertensive effect occurs after 1-2mes.
The decrease angina occurs after the application of Coronal by improving heart muscle perfusion, lengthening of diastole, decrease the oxygen demand of the heart muscle.
Troubleshooting arrhythmia possible because of the ability to overcome Coronal tachycardia, hypertension, the activity of the sympathetic nervous system, reduce the rate of excitation of the sinus and ectopic pacemaker, atrioventricular conduction.
Coronal release tablets 5 mg and 10 mg Coronal.
Coronal instructions prescribed by arterial hypertension, angina, coronary heart disease, myocardial infarction (Coronal serves as preparation of secondary prevention).
Positive reviews of the Coronal, used in the treatment of patients with arrhythmias: sinus tachycardia, supraventricular and ventricular premature beats, arrhythmia due to hyperthyroidism, mitral valve prolapse.
Instructions for use Coronal
For all these indications Coronal take 5 - one tablet a day. In some cases, treatment prescribed reception 2, 5 mg (0, 5 Coronal pills), or increase the dose to 10 mg daily. Acceptable daily dosage - 20mg Coronal (10 mg - for patients with severe renal, liver functions).
Coronal tablet according to the instructions typically take in the morning on an empty stomach or with food. Chew, crush the tablet can not.
At the end of therapy, the abolition of Coronal 5, 10 carried out, gradually reducing the dosage.
Coronal 5, 10mg can cause weakness, fatigue, insomnia, nightmares, depression, headache, drowsiness, anxiety, confusion, a brief loss of memory, hallucinations, tremors, limb paresthesias, myasthenia gravis, fatigue, dryness and soreness of the eyes, reducing the secretion of tears , blurred vision, conjunctivitis, sinus bradycardia.
After Coronal may develop also: Arrhythmia, impaired miokardovoy conductivity, heart rate, atrioventricular block, weakening miokardovoy contractility may develop and worsen chronic heart failure, orthostatic hypotension appear, chest pain, vasoconstriction, reducing the pressure.
There are reviews of Coronal, was summoned to the treatment nausea, dryness of the mouth, abdominal pain, diarrhea, vomiting, changes in taste, impaired liver function, nasal congestion (in high doses), difficulty breathing, laryngospasm, bronchospasm.
Also, the use Coronal can lead to hyperglycemia (in patients with insulin-dependent diabetes), hypoglycemia (in patients taking insulin), allergies, hypothyroid condition, skin redness, rash, cause increased sweating, exacerbation of psoriasis.
Because Coronal may appear back pain, arthralgia, worsening of potency and libido, a syndrome of "cancellation", agranulocytosis, thrombocytopenia, leukopenia, may change the activity of enzymes, bilirubin levels.
Coronal of instruction is contraindicated in: sinoatrial blockade, atrioventricular 2-3y degree, decompensated chronic heart failure, cardiogenic shock, acute heart failure, Prinzmetal angina, bradycardia (a heart rate less than 40 / min), cardiomegaly (with no symptoms of heart failure) arterial hypotension, hypersensitivity.
Do not appoint Koronal5 10 during pregnancy (there are reviews of Coronal, causing intrauterine growth retardation, hypoglycaemia, bradycardia), lactation, patients taking MAO inhibitors, children.
Be wary appoint Koronal5, 10 patients with a history of allergy, diabetes mellitus, chronic obstructive pulmonary disease, pheochromocytoma, liver failure, metabolic acidosis, congestive heart failure, peripheral vascular obliterating disease, hyperthyroidism, depression, psoriasis, myasthenia gravis in the elderly .