Pre - combined hormonal protivoklimakterichesky drug used to reduce the symptoms of menopausal disorders and the treatment of disorders of the menstrual cycle.

Pharmacological action

The active ingredients have Klimena progestin properties, filling the deficit in the body of female hormones.

Estradiol valerate alleviate symptoms that occur due to a decrease in estrogen levels - sweating, hot flashes, irritability, memory impairment, sleep disorders, wrinkles, thinning of the skin, depression, vascular crises, involuntary urination, increased brittle nails, dry mucous membranes of the urinary tract , changes in lipid metabolism and osteoporosis associated with increased bone fragility them.

Cyproterone acetate stops further development of proliferative processes which lead to growth hormone-dependent tumors.

Used as hormone replacement therapy, climate reduces symptoms of menopausal disorders.

Klimov also can be used for irregular menstruation or in her absence, for the resumption of regular monthly bleeding, if the natural menstruation has ended.

With prolonged use of climate control acts as a prophylactic against osteoporosis and cardiovascular disease.

Product form

Klim produced in the form of dragees (coated tablets) of two types:

  • White Pills single component and contains 2 mg estradiol valerate. Excipients - corn starch, lactose monohydrate, povidone 25000, talc, sucrose, magnesium stearate, calcium carbonate, povidone, Macrogol wax;
  • Bicomponent pink pellet containing 2 mg of estradiol valerate and cyproterone acetate 1 mg. Excipients - lactose monohydrate, maize starch, povidone, sucrose, talc, magnesium stearate, macrogol, calcium carbonate, 85% glycerol, titanium dioxide, iron oxide yellow, iron oxide red and wax.

The blister 11 pieces and 10 pieces of white pink pills.

Indications Klimena

In manual climate control is used as a hormone replacement therapy for menopausal disorders that manifest vegetative-vascular, urogenital disorders and psycho, different atrophic processes in the skin, the phenomenon androgenization, involution of the bladder and sexual organs.

Klimov also used according to instructions:

  • When estrogen deficiency after ovariectomy on the oncological diseases;
  • For the treatment of disorders of the menstrual cycle when the primary and secondary amenorrhea;
  • As prevention of osteoporosis in postmenopausal women.


According to the instructions Klimov is contraindicated in:

  • Hormone-dependent tumors;
  • Breast cancer, or if you suspect it;
  • Liver tumors (benign or malignant) and severe liver disease;
  • Severe hypertriglyceridemia;
  • Deep vein thrombosis of the lower limbs.

Klimov also not be used during pregnancy, hypersensitivity to the drug and lactation.

Instructions for use Klimena

 Climate control pills
 Climate control pills taken daily from the fifth to the 25th day of the menstrual cycle. Receiving desirably performed in one and the same time. After completion of receiving the package need to take a break for a week, and then take the next pack of pills. If during the break, the bleeding starts, the drug is taken only after the test to exclude pregnancy.

At menopause, when amenorrhea or bleeding after surgery to remove one or both ovaries climate control pills prescribed for one day regardless of the phases of the cycle for 21 days to one week apart.

In the event of missed doses at the scheduled time, Klimena missed tablet should be taken as soon as possible, within the next 12 hours.

In an application Klimena with anticonvulsants, barbiturates, and certain antibiotics may intensify metabolism components Klim and change the intestinal microflora.

side effects

In manual climate control in most cases well tolerated. Infrequently occur:

  • Flatulence;
  • Changes in body weight and increased appetite;
  • The feeling of tension;
  • Impaired vision and poor tolerance of contact lenses;
  • Dizziness;
  • Skin rash;
  • Discomfort in the epigastric region;
  • Soreness and breast enlargement;
  • Vomiting;
  • Edema;
  • Feeling tired;
  • Nausea,
  • Muscle cramps;
  • Headache and depressed mood;
  • Migraine;
  • Palpitations.

At the beginning of the reception may appear smearing intermenstrual bleeding, changes in vaginal secretion, dysmenorrhea.

Climate control pills should be stopped at first appeared migraine or severe headaches occur often, with a significant increase in blood pressure, with the unexpected hearing or vision and pregnancy.

In overdose Klimenov may increase side effects.

storage conditions

Klimov released under doctor's prescription. The shelf life of the drug - 5 years.