Diprivan - a drug belonging to the anesthetic drugs and used to neingalyatsionnyh general anesthesia.
Structure and Composition
The active ingredient - propofol. The preparation is made in the form of an emulsion for intravenous administration.
According to instructions issued Diprivan ampoules as a solution in white (which during prolonged storage may delaminate slightly). 1 ml solution contains 10 mg of propofol and auxiliary substances (soy bean oil, phospholipids, glycerol, disodium EDTA, sodium hydroxide, sterile water).
In one vial 20 ml of a solution of the drug in one pack 5 vials.
There is also the form of a glass syringe with 50 ml of Diprivan, which is equipped with a polypropylene plunger and Luer connector.
The pharmacological action of Diprivan
Mode of action - obscheanesteziruyuschee. This drug belongs to a short-range facilities for general anesthesia for Diprivan is characterized by rapid onset of action (30 seconds after administration). Out anesthesia after administration of the drug is rapid. Review Diprivan has no sufficient analgesic effect, so is used in combination with other anesthetics.
Diprivan is used for induction of anesthesia (i.e. the introduction of anesthesia) and to maintain it. Propofol has an antiemetic effect and therefore out of anesthesia after its use is not accompanied by nausea, vomiting and headaches.
After the introduction of Diprivan quickly distributed in the body and is rapidly excreted (metabolized mainly by the liver).
- induction (administration) anesthesia, and its maintenance;
- sedation (sedation and relaxation when overexcited) patients undergoing intensive therapy with mechanical ventilation;
- sedation of patients during diagnostic or surgical procedures of short-term.
- a history of allergic reaction to Diprivan (propofol);
- children under the age of 1 month (for the introduction and maintenance of anesthesia);
- diseases such as croup or epiglottitis is a contraindication to the use of the drug;
- age up to 16 years for the purpose of sedation during intensive care;
- age up to 16 years for the purpose of sedation during diagnostic and surgical procedures.
According to the instructions Diprivan should be used with caution in the pathology of the cardiovascular and respiratory systems, as well as kidney and liver in patients with hypovolemia.
Use during pregnancy and lactation
According to the instructions Diprivan should not be used during pregnancy because it crosses the placental barrier and can cause depression of the vital functions of the fetus. This preparation is not used in obstetrics for anesthesia.
However, Diprivan is used during the interruption of pregnancy (I trimester of her).
During lactation not established that the drug is safe for infants. Therefore, if a nursing mother must be the introduction of Diprivan, then breast-feeding should be discontinued for a certain period of time.
Diprivan Instructions: Dosage and administration
Diprivan is administered intravenously (bolus or infusion). Typically, the drug is combined with other anesthetics and can also be combined with the epidural or spinal anesthesia.
For the induction of anesthesia (injection of anesthesia) Diprivan for instructions need to enter a bolus at 40 mg every 10 seconds. The average dose for an adult is 1, 5 - 2, 5 mg / kg body weight. In severe condition of the patient, as well as aged over 55 years, use a lower rate of administration (20 mg in 10 seconds).
To maintain a constant infusion of anesthesia performed (drip) Diprivan, or carried out by repeated bolus injection. When the required infusion rate of administration chosen individually (on average 4-12 mg / kg / hour). In repeated bolus injection requires the introduction of increasing doses (from 25 mg to 50 mg Diprivan).
For sedation during diagnostic and surgical procedures require individual selection of the dosage of the drug. Most patients enough administering 0, 5 - 1 mg / kg of Diprivan for 1-5 minutes.
In the opinion of Diprivan provides a rapid onset of anesthesia without adverse effects. Waking up after using this drug fast and easy.
Side effects of this drug are similar to those that arise when using other obscheanesteziruyuschih funds. In the opinion of Diprivan rarely causes adverse side effects when administered anesthesia.
In 10% of cases there is pain in the injection site during induction of anesthesia. The rest of the side effects occur less frequently. In 1-10% of cases there is hypotension (low blood pressure), bradycardia (slowing of heart rate), blood flow (in children). There may also be headache, nausea and vomiting after leaving the anesthetic. Very rarely during administration of Diprivan may experience temporary apnea (cessation of breathing). Other complications (thrombophlebitis, fever, anaphylaxis, pulmonary edema) occur in less than 0, 1% of cases.
Overdose of this drug may result in inhibition of the function of cardio - vascular and respiratory systems. If respiratory depression should begin artificial respiration (ventilation) with oxygen. If signs of oppression of cardio - vascular system may require administration of plasma expanders and vasopressors (norepinephrine, mezatona et al.).
Interaction with other drugs
According to the instructions, Diprivan can be used in conjunction with epidural and spinal anesthesia, combined with drugs for sedation, muscle relaxants, analgesics and anesthetics inhaled.
Diprivan should not be confused with any infusion solutions except 5% dextrose solution, or injectable lingokaina alfentanil injection.
If used during anesthesia Diprivan, the introduction is carried out after washing relaxants infusion system to prevent mixing of drugs or other infusion line is used.
According to the instructions, Diprivan should be used only by personnel who have been trained in the field of anesthesiology. During the administration of the drug requires constant monitoring of the patient must constantly be ready to use the equipment to maintain the airway, equipment for ventilation, and other means of resuscitation.
Keep in mind that when using Diprivan for sedation during surgical manipulations are possible involuntary movements of patients. Therefore, if the procedure requires immobility should provide fixing the patient.