Digoxin - a cardiac glycoside extracted from the foxglove.
Structure and Composition
The drug is available in the form of white tablets in a dosage of 0, 25 mg, 20 tablets per blister.
The active ingredient - digoxin.
Auxiliary components - vaseline oil, calcium stearate, starch, glucose, talc, sugar.
Digoxin is sold by prescription.
The drug digoxin has a vasodilator, inotropic and moderately diuretic.
Digoxin increases the refractory period, increases in systolic and stroke volume of the heart, atrioventricular conduction and reduces the frequency of contractions of the heart muscle.
With cardiovascular disease the drug has a pronounced vasodilating effect. Its use reduces shortness of breath, reduces the severity of edema, has a mild diuretic effect.
Digoxin - indications for use
Digoxin is prescribed according to the instructions at:
- congestive (chronic) cardiovascular disease;
- paroxysmal supraventricular tachyarrhythmias - paroxysmal tachycardia, atrial fibrillation, atrial fibrillation.
Digoxin Instructions: Method of application and dosage
The dosage of digoxin according to the instructions picks individually physician.
Adult Digoxin shown in a single dose - 1 tablet (0, 25 mg). On the first day of treatment take medication four to five times a day at regular intervals. The daily dosage is 1-1, 25 mg. From the second day of treatment the dosage is reduced to 1 tablet. Depending on the positive effect of the doctor adjusts the dosage - increases or reduces it. After the therapeutic effect of the drug taken by the scheme: in the morning - 2 pills at lunchtime - 1 tablet before bedtime - 0, 5 tablets.
With Digoxin Cardiovascular disease is shown in a maintenance dose - 0 5-1 tablet per day. At the beginning of treatment arrhythmia allowed the use of higher doses - 1, 5-2 tablets per day. If sinus rhythm Digoxin prescription dosage is 1 tablet per day.
For children, the dosage selection Digoxin prescription carried out individually. The estimated daily infant dose is 0, 05-0, 08 mg per kilogram of body weight.
Failure to follow instructions Digoxin can cause the following side effects:
- Gastrointestinal tract: nausea, diarrhea, vomiting, loss of appetite;
- The endocrine system: the long-term treatment may gynecomastia;
- Cardiovascular system: as a consequence of an overdose - change in heart rate;
- Central nervous system: psychosis, flickering flies, photophobia, depression, fatigue, diplopia, lethargy, headaches;
- Hemopoietic system: thrombocytopenia, petechiae;
- Allergies: rash, itching.
All side effects mainly caused by failure to receive Digoxin prescription.
Contraindications to the use of Digoxin
Digoxin is contraindicated for instructions:
- Digitalis intoxication;
- When arrhythmias (atrioventricular block, ventricular fibrillation, ventricular tachycardia, arrythmia, bradycardia);
- In unstable angina;
- When cardiac tamponade;
- The syndrome of Wolff-Parkinson-White syndrome;
- In acute myocardial infarction;
- When subortalnom hypertrophic stenosis;
- When mitral stenosis;
- If you are hypersensitive to the components of the drug.
The use of digoxin in pregnancy and lactation
The drug penetrates the blood-placenta barrier, blood plasma is concentrated in the fetus in the same amount as that of the mother.
To a small extent excreted in breast milk. While taking Digoxin prescription during lactation requires constant monitoring of the heart rate of the child.
Thus, Digoxin shows pregnant women only if the potential benefit outweighs the risk of mother disorders in the fetus.
Interaction with Drug
Digoxin for instructions incompatible with acids, tannins, salts, metals, alkalis. In conjunction with the glucocorticosteroid means sympathomimetics, diuretics, insulin and drugs calcium increases the risk of glycoside intoxication.
In combination with erythromycin, verapamil, quinidine and amiodarone is an increase in the blood concentration of digoxin. Quinidine reduces its excretion from the body.
The simultaneous use of Digoxin and verapamil reduces its renal clearance.
The combination of the drug with amphotericin B increases the risk of overdose. In combination with phenytoin, reserpine, propranolol increases the likelihood of developing arrhythmias.
Reduces the effectiveness of the drug means barbituric series and phenylbutazone. Also, reduce the therapeutic effect of neomycin, metoclopramide, potassium supplements and antacids.
Simultaneous treatment with colestipol, metoclopramide, cholestyramine, magnesium laxatives and antacids cause a decrease in the concentration of the active substance in the blood.