Diferelin - for the treatment of various diseases of the reproductive system in men and women.
Pharmacological action Diferelin
Diferelin inhibits the secretion of the hormone gonadotropin and, consequently, inhibits the function of the ovaries and testes.
Prolonged use of the drug inhibits the production of estrogen in women, testosterone in men.
The active ingredient of the drug - triptorelin.
Producing Valium for breeding suspension for intramuscular injections.
According to the instructions Diferelin prescribed for endometriosis and extra-genital, prostate cancer, uterine fibroids (prior to surgery), with early puberty.
There are reviews of Diferelin successfully used in infertility in women - with their preparation for in vitro fertilization.
Instructions Diferelin: methods of use
Patients suffering from prostate cancer, makes one injection every four weeks of medication - 3, 75 mg. In this case, we recommend holding long-term therapy.
For treatment of early sexual maturation in patients weighing more than 20 kg are administered every 28 days Diferelin at 3, 75 mg, patients weighing less than 20 kg administered 1, 875 mg.
For the treatment of endometriosis Diferelin administered every four weeks during the first five days of the menstrual cycle in a dose of 3, 75 mg. Judging by the reviews of Diferelin treatment lasts no more than six months.
For the treatment of female infertility appoint 3, 75 mg: in the 2nd day of the menstrual cycle, do one injection Diferelin.
When uterine fibroids patients preparing for surgery, the drug is administered during the first 5 days of the menstrual cycle is administered 3, 75 mg every four weeks. Therapy lasts for 3 months.
Diferelin injections can only be done intramuscularly.
Side effects of injections Diferelin
Diferelin can cause itching, hives, vomiting, nausea, hypertension, impaired vision, and emotional lability (rare), angioedema, bone demineralization, weight gain, pain at the injection site, fever, obstruction of the ureter, a short increase in acid phosphatase activity.
In men, there may be a deterioration in potency in women - depression, change in libido, sweating, dryness of the vaginal mucosa, changes in breast size.
Girls who Diferelin appointed for the treatment of early puberty, vaginal discharge may begin with blood.
Prolonged drug therapy in women can cause amenorrhea.
There are reviews of Diferelin that caused during the treatment of prostate cancer increased pain in the bones, which are spread metastases.
Diferelin can not be taken by pregnant women, breastfeeding, hypersensitivity to the drug and its analogues. With care take medication for osteoporosis, polycystic ovaries.
Men who undergo treatment for prostate cancer, during the 1st month of the drug should be under medical supervision, because they can worsen symptoms. Under particular scrutiny are the patients who have an increased risk of spinal cord compression or obstruction of the ureter.
When planning a pregnancy take into account that after the withdrawal of the drug in women restored ovarian function and 57 days after the last injection Diferelin begins ovulation. The first menstrual bleeding begins 69 days after the last injection (70 minutes daily).