Co-trimoxazole - a drug with antimicrobial action from the group of sulfonamides.
Co-trimoxazole - a broad spectrum of action, suppresses the development of corynebacteria, staphylococci, gonococci, streptococci, E. coli, Shigella, Salmonella, Proteus, Enterobacteriaceae Klebsiella, iersenii, cholera, Haemophilus influenzae, Bacteroides, chlamydia.
Resistant to co-trimoxazole Pseudomonas aeruginosa, pallidum, Mycoplasma, Mycobacterium tuberculosis (Mycobacterium tuberculosis).
The active ingredients of the drug: sulfamethoxazole and trimethoprim.
Indications for use of co-trimoxazole
The drug is used for infections of the respiratory system: tonsillitis, bronchiectasis, empyema, chronic bronchitis, lung abscess, pharyngitis, pneumonia; infections of the urogenital system: cystitis, prostatitis, urethritis gonococcal, medicine and other; Gastrointestinal infections: typhoid, cholangitis, enteritis, cholecystitis, paratyphoid, dysentery; soft tissue infections, skin: furunculosis, pyoderma, wound infection.
There are positive reviews of co-trimoxazole used for the treatment of brucellosis, septicemia.
Instructions Co-trimoxazole: how to use
Intravenously or intramuscularly injected every 12 hours co-trimoxazole. For children after 12l., 960mg administered to adults at one time, children 2-6mes. - 120mg, children 6mes.-5L. - 240 mg, children 6-12l. - 480mg.
Take co-trimoxazole in acute infections is necessary to complete disappearance of clinical symptoms, and two days after that. The average treatment lasts for 5days.
Treatment of urinary tract infections, exacerbated chronic bronchitis, acute otitis average, chlamydia, chancroid drug co-trimoxazole lasts 10-14dn .; infections afflicting lower urinary ducts, uneventful - 1-3 days; shigellosis, diarrhea, "traveler" - 5d .; Acute brucellosis - 3-4ned .; paratyphoid or typhoid fever - 1-3mes .; chronic prostatitis - 3-month.
In order to prevent the resumption of urinary tract infection a chronic nature, occurring without bacteriuria children after 12l., Adult co-trimoxazole 480mg administered one p / day, children under 12 liters. - 2 mg per kg of trimethoprim and 10 mg sulfamethoxazole per kilogram of child's weight per day. Treatment for 3-12 months.
When pneumonia is caused by bacteria Pneumocystis carinii, co-trimoxazole for instructions prescribe high dose: 15-20mg / kg of trimethoprim and sulfamethoxazole - 75-100mg / kg. Take co-trimoxazole in 4 divided doses, for 14-21dn.
For the treatment of uncomplicated gonorrhea take co-trimoxazole 480mg two p / day for two days or a pattern: for the first time take 2, 4g of the drug through 8h - another 2, 4 g.
For the treatment of gonococcal infections of the mucous nasopharynx is an effective dose of co-trimoxazole 960mg, which take 3 p / day. for 7d.
For the treatment of malaria, Plasmodium falciparum provoked by bacteria take 1, 92g Co-trimoxazole 2 p / day for two days.
After the application of co-trimoxazole may occur vomiting, glossitis, cholestatic hepatitis, nausea, diarrhea, colitis psevdomembranoobrazny, Lyell's syndrome, angioedema, skin rash, Stevens-Johnson syndrome, neutropenia, anemia, megaloblastic, thrombocytopenia, leukopenia, agranulocytosis, interstitial nephritis, hematuria , crystalluria, phlebitis, purpura.
There are reviews of co-trimoxazole, causes a disturbance of the thyroid gland.
The risk of side effects increases in patients suffering from AIDS in the elderly. Elderly patients are advised to combine the drug with folic acid.
During the prolonged therapy with co-trimoxazole monitor the condition of the kidneys, liver, peripheral blood.
Do not take the drug for diseases of the blood, sensitivity to sulfonamides, trimethoprim, functional disorders of the kidneys, liver, deficiency of glucose-6-phosphate dehydrogenase, lactating and pregnant women.
According to the instructions co-trimoxazole prescribed with caution in cases of suspected lack of folic acid in the presence of past allergies, bronchial asthma, disorders of the kidney, thyroid, liver.
The simultaneous use of co-trimoxazole sulfonylureas can cause hypoglycemia. With the combination of the drug indirect anticoagulants action slows down the latter.
Besides, judging by the reviews of co-trimoxazole, it increases the toxicity of methotrexate can cause thrombocytopenia, particularly in elderly patients, in combination with a diuretic.
Active co-trimoxazole is enhanced by the naproxen inometatsina, butadiona, salicylates, increasing the likelihood of side effects.