Artezin - synthetic antihypertensive drug used for the treatment of benign prostatic hyperplasia.
The active substance Artezina hypotensive effect. The maximum reduction in blood pressure while standing and lying down was after 3-6 hours after a single dose of the drug and lasts throughout the day. Artezin of instruction is effective in hypertension complicated by obesity and impaired glucose tolerance.
The drug also reduces the risk of coronary heart disease, and after applying Artezina for two weeks there is a persistent decrease in the symptoms of benign prostatic hyperplasia.
Artezin produced in the form of white to cream colored spigot tablets containing 1, 2, and 4 mg of doxazosin. 10 tablets in contour packaging.
Other ingredients - microcrystalline cellulose, lactose, potato starch, magnesium stearate, sodium lauryl sulfate, povidone, colloidal silicon dioxide.
According to the instructions Artezin apply:
- For the treatment of hypertension. This drug is used in monotherapy or concomitantly with other antihypertensive agents;
- For the treatment of benign prostatic hyperplasia. Artezin can be applied both at elevated and with normal blood pressure.
Artezin for instructions apply contraindicated in case of hypersensitivity to the active substance - doxazosin and quinazolone derivatives or other components included in the tablets. Use the drug during pregnancy and lactation is possible only under strict conditions, since reliable data about the safety of its use during these periods is not.
It is also not recommended for prostate Artezin tablets of 2 and 4 mg under the age of 18 years.
Caution should be exercised when using the drug in orthostatic hypotension, aortic and mitral stenosis and hepatic dysfunction.
Dosing instructions for Artezina
According to the instructions Artezin taken regardless of meals one tablet once a day, morning or evening. The daily dose and duration of treatment depends on the disease and determined by the physician.
The initial daily dose for hypertension is 1 mg Artezina. The drug is taken at bedtime, after the first dose necessary to comply with bed rest for 6-8 hours in order to avoid the development of side effects, manifested as "a phenomenon of the first dose." If the therapeutic effect is insufficient after a few weeks the daily dose can be doubled. Subsequently gradually every few weeks the dose may be increased to 2 mg and effective, which is typically 8 mg.
Do not take more than 16 mg per day Artezina. After reaching a stable therapeutic effect dose recommended to reduce maintenance, which is generally from 2 to 4 mg per day Artezina.
In the treatment of prostatitis Artezinom necessary to exclude malignant tumors of the prostate before treatment. The initial dose is 1 mg per day, which, if necessary, can be increased to 2-4 mg per day. The maximum daily dose for the treatment of prostatitis Artezinom should not exceed 8 mg.
In case of overdose can occur Artezinom marked reduction in blood pressure, which may be accompanied by syncope.
The drug can be used in conjunction with beta-blockers, indirect anticoagulants, oral hypoglycemic agents, thiazide diuretics, furosemide, ACE inhibitors, calcium channel blockers slow, antibiotics and uricosuric agents.
Nonsteroidal anti-inflammatory drugs, sympathomimetics and estrogens may reduce the hypotensive effect Artezina. With the simultaneous use of the drug with phosphodiesterase inhibitors Caution should be exercised because of the possible increase the hypotensive action.
In the treatment of hypertension according to the instructions Artezin often cause orthostatic hypotension, especially at the beginning of treatment. Also, the drug can cause reviews of fainting, swelling, dizziness, drowsiness, fatigue, headache, nausea, rhinitis, asthenia, malaise and in rare cases - myocardial infarction, angina pectoris, bradycardia, cerebrovascular accident, palpitations, tachycardia, pain chest and arrhythmia.
In the treatment of prostatitis Artezinom addition to the above side effects may also occur:
- Dry mouth, hypoesthesia, priapism, irritability, impotence, paraesthesia, tremor and insomnia;
- Muscle spasms, arthralgia, muscle weakness, and myalgia;
- Skin rash, and urticaria;
- Bronchospasm, dyspnea, cough, epistaxis;
- Dysuria, impaired urination, hematuria, polyuria, nocturia and incontinence;
- The decrease in blood pressure and orthostatic hypertension;
- Loss of appetite, diarrhea, abdominal pain, hepatitis, constipation, elevated liver enzymes, dyspepsia, flatulence, jaundice, nausea and cholestasis;
- Purpura, leukopenia and thrombocytopenia;
- Blurred vision and ringing in the ears;
- Back pain and a sensation of heat.
Drinking alcohol can exacerbate unwanted side effects Artezina.
Artezin refers to the list B and prescription drug recommended shelf life - 3 years.