Amphotericin B - antibacterial drug with antifungal activity.
Mode of action Amphotericin B
Amphotericin B is active against yeast-like fungi, pathogens fungal infection, cryptococcosis, blastomycosis, histoplasmosis, sporotrichosis.
Amphotericin B for intravenous administration is highly toxic.
Producing Amphotericin B Ointment solution.
Amphotericin B inhalation, intravenous prescribed for candidiasis of internal organs, digestive tract, chronic and disseminated granulomatous forms of candidiasis, with cryptococcosis, coccidioidomycosis, histoplasmosis, chromomycosis, North American blastomycosis, aspergillosis, mold mycosis, sporotrichosis.
Amphotericin B is used in the ointment and skin mucosal candidiasis.
Instructions amphotericin B, method of application
The therapeutic dosage of the drug is calculated from its weight: 250 U / kg. If the treatment side effects appear, the dose can, if necessary, be increased to 1000ED / kg.
Amphotericin B is administered according to the instructions recommended 1-2r. a week or every other day - in order to avoid the accumulation of the antibiotic in the blood.
The duration of therapy depends on the patient, and the disease is not less 4-8ned.
The average for the full course of treatment is carried out 18-20 infusions of amphotericin B (1 5-2mln ED).
A solution is prepared immediately before administration, it should be taken into account that it can not be exposed to light. Amphotericin B diluted with glucose 5%. If a pellet preparation can not be administered.
Inhalation amphotericin B is conducted one or two rows / day. Lasts 15-20min procedure, one has to inhale 10ml. Acceptable daily dosage 1000-2000ED / kg. If the inhaler is used for inhalation, which works only on inhalation, the dosage was reduced to 5 ml. The course of treatment usually lasts 10-14 days, the treatment can be repeated after 7-10 days to pass.
Solution for inhalation also be prepared freshly before procedure: The contents of the vial with the antibiotic was dissolved in 10 ml of water for injection.
Ointments amphotericin B is used exclusively externally: 2-4 p / day treated areas of skin damaged by fungus. The duration of treatment of candidiasis skin folds - 1-3 weeks, baby diaper rash - 1-2 weeks, fungal lesions and paronychia fingers - 2-4 weeks.
Side effects of amphotericin B
When administered intravenously, after inhalation using the drug amphotericin B, may be nausea, epigastric pain, appetite loss and vision, vomiting, leukopenia, anemia, headache, diplopia, neuropathy, arrhythmia, hypertension, azotemia, hypokalemia, proteinuria, acidosis , pruritus, rash, angioedema, bronchospasm, allergic contact dermatitis, runny nose, sore throat, cough, chills, fever.
After the ointment Amphotericin B may feel a tingling, dryness and burning, the skin may be red.
Amphotericin B can not be used in diabetes, expressed human liver, kidneys, blood system diseases, hypersensitivity.