Albumin - a formulation intended for parenteral nutrition, which is a partial substitute for blood plasma.
Release form and composition
Release of 5, 10 and 20% albumin solution for intravenous administration. It looks like a transparent viscous liquid. The active ingredient in its composition the protein albumin is isolated from human plasma. Auxiliaries are the sodium chloride, sodium kaprilovokisly and water for injection.
The solution is discharged in the ampoule 10 and 20 ml, and in bottles of 50, 100, 200 and 400 ml.
According to the instructions, Albumin should be used with the following pathological conditions and diseases:
- Traumatic, toxic, hemorrhagic, purulent-septic, operational shock;
- Severe burns;
- Nephritis with nephrotic syndrome;
- Hemolytic disease of the newborn;
- Liver disease with impaired protein synthesis;
- Ascites (fluid in the abdominal cavity);
- Diseases of the digestive malabsorption of protein (peptic ulcer with decompensated stenosis, impaired patency of anastomoses);
- Respiratory distress syndrome in adults;
- Long-pyo-septic diseases with the development of protein deficiency;
- Swelling of the brain;
- Hemodialysis, therapeutic plasmapheresis;
- Operations using cardiopulmonary bypass.
Contraindications to the use of albumin are:
- Congestive heart failure;
- Continued bleeding;
- arterial hypertension;
- Chronic renal failure;
- Hypersensitivity to albumin;
- pulmonary edema;
In chronic diseases of the heart drug should be used with caution, as there is a risk of acute heart failure.
It will be appreciated that means increases blood pressure due to positive oncotic activity. Therefore, after the transfusion of the drug in postoperative and posttraumatic period may start bleeding from damaged vessels, which previously due to the low pressure does not bleed.
Mandatory monitoring by a doctor during and after the infusion.
Dosage and Administration
According to the instructions, albumin is administered intravenously at a rate of 50-60 drops (3 ml) per minute.
The daily volume of solution is 100-500 ml.
For each patient, the dose is selected individually depending on the severity of the condition, the clinical picture and age.
Typically prescribed 10% albumin solution. The mean dose calculated from the formula: 1-2 ml / kg. Intravenous administered daily or every other day to achieve the effect.
20% solution is used in severe cases. It is contraindicated in patients of advanced age.
It is important to observe the rate of infusion, since more rapid introduction can occur dysfunction cardiovascular system.
When albumin transfusion side effects are extremely rare. The manifestation of side effects in the form of allergic reactions may have previously sensitized individuals (those who already had infusions of the protein albumin).
They can also occur if the patient has a history of indications reactions after transfusions of plasma, vaccines and serums. From allergic complications may occur urticaria, angioedema, fever, low blood pressure, anaphylactic shock.
In the event of allergic reactions infusion solution should be discontinued and not removing the needle from the vein of the vessel to enter the patient antihistamines, cardiac facilities.
Before applying Albumin should inspect the vial for the presence of sludge, the slurry color changes. If any such indication drug use is prohibited. If the vial has been used not completely, you can not use it again. In order to prevent complications of bacterial use cracked, damaged or previously opened vials of solution.
There is no information on the impact of the drug on the fetus in pregnant women, therefore the use of albumin in this period is only possible under strict indications.
The introduction of the drug can be carried out in conjunction with the transfusion of blood components (red cell, whole blood), electrolyte solutions. However, it can not be mixed with solutions of amino acids and alcohol-based solutions.
The most common solution is analogous drugs Plazbumin 20, Uman albumin, human albumin 20% and 20 Zenalb.
Terms and conditions of storage
According to the instructions, albumin should be stored at a temperature of 2-10 ° C.
Shelf life is 5 years.